Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2285229..2285699 Replicon chromosome
Accession NZ_CP073835
Organism Staphylococcus epidermidis strain B1230143

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag KFV52_RS11410 Protein ID WP_001829569.1
Coordinates 2285511..2285699 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag KFV52_RS13840 Protein ID WP_002438963.1
Coordinates 2285229..2285486 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV52_RS11375 (KFV52_11385) 2280593..2281309 - 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -
KFV52_RS11380 (KFV52_11390) 2281470..2281892 + 423 WP_002457221.1 organic hydroperoxide resistance protein -
KFV52_RS11385 (KFV52_11395) 2282076..2282231 - 156 WP_001829648.1 hypothetical protein -
KFV52_RS11390 (KFV52_11400) 2282817..2283317 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
KFV52_RS11395 (KFV52_11405) 2283588..2284175 - 588 WP_001829615.1 histidine phosphatase family protein -
KFV52_RS11400 (KFV52_11410) 2284389..2284625 + 237 WP_002457224.1 hypothetical protein -
KFV52_RS11405 (KFV52_11415) 2284617..2284820 - 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
KFV52_RS13840 2285229..2285486 + 258 WP_002438963.1 hypothetical protein Antitoxin
KFV52_RS11410 (KFV52_11420) 2285511..2285699 + 189 WP_001829569.1 hypothetical protein Toxin
KFV52_RS11415 (KFV52_11425) 2285889..2286443 + 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
KFV52_RS11420 (KFV52_11430) 2286503..2286736 - 234 WP_001829664.1 hypothetical protein -
KFV52_RS11425 (KFV52_11435) 2287020..2287766 + 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
KFV52_RS11430 (KFV52_11440) 2287865..2288149 + 285 WP_001829635.1 hypothetical protein -
KFV52_RS11435 (KFV52_11445) 2288173..2288397 + 225 WP_001829613.1 hypothetical protein -
KFV52_RS11440 (KFV52_11450) 2289018..2289218 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2276201..2300485 24284
- flank IS/Tn - - 2282076..2282231 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(12-88)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T200365 WP_001829569.1 NZ_CP073835:2285511-2285699 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T200365 NZ_CP097836:104728-105213 [Shigella flexneri]
ATGGGATGTGTAACTGCACCAGAACCTTTATCCTCATTTCATCAGGTCGCTGAATTTGTCAGCAGTGAAGCTGTACTTGA
TGACTGGTTAAAGCAGAAGGAGCTAAAAAATCAGGCAATCGGAGCCACCCGGACTTTTGTTGTATGCAGAAAAGGTACGC
AACAAATAGTCGGTTTTTACTCACTGGCCACTGGTAGTGTCAATCATACAGAAGCTACAGGTAACCTTCGGCGCAATATG
CCAGACCCCATTCCTGTAATTATACTTGCACGCCTGGCTGTAGATGTGTCATTTCGAGGAAAAGGGCTTGGCGCGGATTT
ACTTCATGATGCAGTTCGTCGTTGTTACAGGGTTGCCGAAAATATCGGTGTGCGTGCAATTATGGTTCATGCGCTTACGG
AAAACGCAAAACAGTTTTATATTCATCATGGTTTTAAGCCATCAAAAACTCAGGTGCAAACATTGTTTCTTAAACTCCCT
CAATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT200365 WP_002438963.1 NZ_CP073835:2285229-2285486 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT200365 NZ_CP097836:104456-104740 [Shigella flexneri]
ATGATATACGGAGGCTTTATGAAATCAGGTGTTCAGCTCAATCTCAGAGCAAGAGAATCACAGCGGATACTCATTGATGC
TGCTGCAGAAATTCTTCATAAGTCGCGTACAGATTTCATTCTGGAAATGGCCTGTAAAGCTGCTGAAGATGTTATTCTCG
ACCGGCGGGTGTTTAATTTTAATGACAGGCAATATGAAGAGTTCATTGAAATGCTTGATGCTCCGGTTGCAGATGATCCT
GCCATCGAAAAATTGCTGGCAAGGAAACCTCAATGGGATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References