Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2070703..2071212 Replicon chromosome
Accession NZ_CP073835
Organism Staphylococcus epidermidis strain B1230143

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KFV52_RS10230 Protein ID WP_001829980.1
Coordinates 2070703..2070912 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KFV52_RS10235 Protein ID WP_001829893.1
Coordinates 2070919..2071212 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV52_RS10210 (KFV52_10220) 2066281..2067636 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KFV52_RS10215 (KFV52_10225) 2067648..2068721 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KFV52_RS10220 (KFV52_10230) 2069112..2070323 + 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KFV52_RS10225 (KFV52_10235) 2070423..2070560 - 138 WP_001829949.1 Lmo0850 family protein -
KFV52_RS10230 (KFV52_10240) 2070703..2070912 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KFV52_RS10235 (KFV52_10245) 2070919..2071212 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KFV52_RS10240 (KFV52_10250) 2071386..2072870 + 1485 WP_002457116.1 cardiolipin synthase -
KFV52_RS10245 (KFV52_10255) 2073052..2073705 + 654 WP_001829983.1 HD domain-containing protein -
KFV52_RS10250 (KFV52_10260) 2073811..2074683 - 873 WP_002458703.1 membrane protein insertase YidC -
KFV52_RS10255 (KFV52_10265) 2074772..2075410 - 639 WP_002505076.1 thiamine phosphate synthase -
KFV52_RS10260 (KFV52_10270) 2075416..2076204 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T200364 WP_001829980.1 NZ_CP073835:c2070912-2070703 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T200364 NZ_CP097836:c16332-16057 [Shigella flexneri]
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAGAACAGGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT200364 WP_001829893.1 NZ_CP073835:c2071212-2070919 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT200364 NZ_CP097836:c16616-16332 [Shigella flexneri]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGTCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References