Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 2247925..2248395 | Replicon | chromosome |
| Accession | NZ_CP073830 | ||
| Organism | Staphylococcus epidermidis strain B1220165 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q5HQS5 |
| Locus tag | KFV27_RS10920 | Protein ID | WP_001829569.1 |
| Coordinates | 2248207..2248395 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | D4FNP2 |
| Locus tag | KFV27_RS13440 | Protein ID | WP_002438963.1 |
| Coordinates | 2247925..2248182 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV27_RS10885 (KFV27_10895) | 2243289..2244005 | - | 717 | WP_001831974.1 | type I 3-dehydroquinate dehydratase | - |
| KFV27_RS10890 (KFV27_10900) | 2244166..2244588 | + | 423 | WP_002457221.1 | organic hydroperoxide resistance protein | - |
| KFV27_RS10895 (KFV27_10905) | 2244772..2244927 | - | 156 | WP_001829648.1 | hypothetical protein | - |
| KFV27_RS10900 (KFV27_10910) | 2245513..2246013 | + | 501 | WP_001829623.1 | GNAT family N-acetyltransferase | - |
| KFV27_RS10905 (KFV27_10915) | 2246284..2246871 | - | 588 | WP_001829615.1 | histidine phosphatase family protein | - |
| KFV27_RS10910 (KFV27_10920) | 2247085..2247321 | + | 237 | WP_002457224.1 | hypothetical protein | - |
| KFV27_RS10915 (KFV27_10925) | 2247313..2247516 | - | 204 | WP_002438966.1 | sterile alpha motif-like domain-containing protein | - |
| KFV27_RS13440 | 2247925..2248182 | + | 258 | WP_002438963.1 | hypothetical protein | Antitoxin |
| KFV27_RS10920 (KFV27_10930) | 2248207..2248395 | + | 189 | WP_001829569.1 | hypothetical protein | Toxin |
| KFV27_RS10925 (KFV27_10935) | 2248585..2249139 | + | 555 | WP_001829566.1 | lipoprotein N-acylation protein LnsA | - |
| KFV27_RS10930 (KFV27_10940) | 2249199..2249432 | - | 234 | WP_001829664.1 | hypothetical protein | - |
| KFV27_RS10935 (KFV27_10945) | 2249716..2250462 | + | 747 | WP_002438959.1 | poly-gamma-glutamate hydrolase family protein | - |
| KFV27_RS10940 (KFV27_10950) | 2250561..2250845 | + | 285 | WP_001829635.1 | hypothetical protein | - |
| KFV27_RS10945 (KFV27_10955) | 2250869..2251093 | + | 225 | WP_001829613.1 | hypothetical protein | - |
| KFV27_RS10950 (KFV27_10960) | 2251714..2251914 | - | 201 | WP_001829681.1 | cold-shock protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2244772..2244927 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7229.94 Da Isoelectric Point: 9.7844
>T200360 WP_001829569.1 NZ_CP073830:2248207-2248395 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
Download Length: 189 bp
>T200360 NZ_CP097834:3709194-3709469 [Shigella flexneri]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGAAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
TGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGAAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
TGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 10014.05 Da Isoelectric Point: 4.5440
>AT200360 WP_002438963.1 NZ_CP073830:2247925-2248182 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
Download Length: 258 bp
>AT200360 NZ_CP097834:3709466-3709825 [Shigella flexneri]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGTATTCAGGGGCTGCAAAAAGAAGGAG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGTATTCAGGGGCTGCAAAAAGAAGGAG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0N0LUH8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U5IVM3 |