Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2033399..2033908 Replicon chromosome
Accession NZ_CP073830
Organism Staphylococcus epidermidis strain B1220165

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KFV27_RS09740 Protein ID WP_001829980.1
Coordinates 2033399..2033608 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KFV27_RS09745 Protein ID WP_001829893.1
Coordinates 2033615..2033908 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV27_RS09720 (KFV27_09730) 2028977..2030332 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KFV27_RS09725 (KFV27_09735) 2030344..2031417 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KFV27_RS09730 (KFV27_09740) 2031808..2033019 + 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KFV27_RS09735 (KFV27_09745) 2033119..2033256 - 138 WP_001829949.1 Lmo0850 family protein -
KFV27_RS09740 (KFV27_09750) 2033399..2033608 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KFV27_RS09745 (KFV27_09755) 2033615..2033908 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KFV27_RS09750 (KFV27_09760) 2034082..2035566 + 1485 WP_002457116.1 cardiolipin synthase -
KFV27_RS09755 (KFV27_09765) 2035748..2036401 + 654 WP_001829983.1 HD domain-containing protein -
KFV27_RS09760 (KFV27_09770) 2036507..2037379 - 873 WP_002458703.1 membrane protein insertase YidC -
KFV27_RS09765 (KFV27_09775) 2037468..2038106 - 639 WP_002505076.1 thiamine phosphate synthase -
KFV27_RS09770 (KFV27_09780) 2038112..2038900 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T200359 WP_001829980.1 NZ_CP073830:c2033608-2033399 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T200359 NZ_CP097834:3629422-3629529 [Shigella flexneri]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT200359 WP_001829893.1 NZ_CP073830:c2033908-2033615 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT200359 NZ_CP097834:c3629365-3629310 [Shigella flexneri]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References