Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2247452..2247922 Replicon chromosome
Accession NZ_CP073827
Organism Staphylococcus epidermidis strain B1208538

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag KFV36_RS10955 Protein ID WP_001829569.1
Coordinates 2247734..2247922 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag KFV36_RS13495 Protein ID WP_002438963.1
Coordinates 2247452..2247709 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV36_RS10920 (KFV36_10930) 2242816..2243532 - 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -
KFV36_RS10925 (KFV36_10935) 2243693..2244115 + 423 WP_002457221.1 organic hydroperoxide resistance protein -
KFV36_RS10930 (KFV36_10940) 2244299..2244436 - 138 WP_162161215.1 hypothetical protein -
KFV36_RS10935 (KFV36_10945) 2245040..2245540 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
KFV36_RS10940 (KFV36_10950) 2245811..2246398 - 588 WP_001829615.1 histidine phosphatase family protein -
KFV36_RS10945 (KFV36_10955) 2246612..2246848 + 237 WP_002457224.1 hypothetical protein -
KFV36_RS10950 (KFV36_10960) 2246840..2247043 - 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
KFV36_RS13495 2247452..2247709 + 258 WP_002438963.1 hypothetical protein Antitoxin
KFV36_RS10955 (KFV36_10965) 2247734..2247922 + 189 WP_001829569.1 hypothetical protein Toxin
KFV36_RS10960 (KFV36_10970) 2248112..2248666 + 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
KFV36_RS10965 (KFV36_10975) 2248726..2248959 - 234 WP_001829664.1 hypothetical protein -
KFV36_RS10970 (KFV36_10980) 2249243..2249989 + 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
KFV36_RS10975 (KFV36_10985) 2250088..2250372 + 285 WP_001829635.1 hypothetical protein -
KFV36_RS10980 (KFV36_10990) 2250396..2250620 + 225 WP_001829613.1 hypothetical protein -
KFV36_RS10985 (KFV36_10995) 2251241..2251441 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2244299..2244454 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-133)

Antitoxin

Vibrio phage ICP1, Orf50

(19-96)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T200355 WP_001829569.1 NZ_CP073827:2247734-2247922 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T200355 NZ_CP097834:2350292-2350753 [Shigella flexneri]
TTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACTG
TGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAGAC
AACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGGAGCGCGG
AAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAAAAATTCACCCGGCATTACC
AATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCGA
CACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT200355 WP_002438963.1 NZ_CP073827:2247452-2247709 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT200355 NZ_CP097834:2349909-2350220 [Shigella flexneri]
ATGCCTGGAAAAACAGCCGCTCTATACGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References