Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 2247452..2247922 | Replicon | chromosome |
| Accession | NZ_CP073827 | ||
| Organism | Staphylococcus epidermidis strain B1208538 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q5HQS5 |
| Locus tag | KFV36_RS10955 | Protein ID | WP_001829569.1 |
| Coordinates | 2247734..2247922 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | D4FNP2 |
| Locus tag | KFV36_RS13495 | Protein ID | WP_002438963.1 |
| Coordinates | 2247452..2247709 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV36_RS10920 (KFV36_10930) | 2242816..2243532 | - | 717 | WP_001831974.1 | type I 3-dehydroquinate dehydratase | - |
| KFV36_RS10925 (KFV36_10935) | 2243693..2244115 | + | 423 | WP_002457221.1 | organic hydroperoxide resistance protein | - |
| KFV36_RS10930 (KFV36_10940) | 2244299..2244436 | - | 138 | WP_162161215.1 | hypothetical protein | - |
| KFV36_RS10935 (KFV36_10945) | 2245040..2245540 | + | 501 | WP_001829623.1 | GNAT family N-acetyltransferase | - |
| KFV36_RS10940 (KFV36_10950) | 2245811..2246398 | - | 588 | WP_001829615.1 | histidine phosphatase family protein | - |
| KFV36_RS10945 (KFV36_10955) | 2246612..2246848 | + | 237 | WP_002457224.1 | hypothetical protein | - |
| KFV36_RS10950 (KFV36_10960) | 2246840..2247043 | - | 204 | WP_002438966.1 | sterile alpha motif-like domain-containing protein | - |
| KFV36_RS13495 | 2247452..2247709 | + | 258 | WP_002438963.1 | hypothetical protein | Antitoxin |
| KFV36_RS10955 (KFV36_10965) | 2247734..2247922 | + | 189 | WP_001829569.1 | hypothetical protein | Toxin |
| KFV36_RS10960 (KFV36_10970) | 2248112..2248666 | + | 555 | WP_001829566.1 | lipoprotein N-acylation protein LnsA | - |
| KFV36_RS10965 (KFV36_10975) | 2248726..2248959 | - | 234 | WP_001829664.1 | hypothetical protein | - |
| KFV36_RS10970 (KFV36_10980) | 2249243..2249989 | + | 747 | WP_002438959.1 | poly-gamma-glutamate hydrolase family protein | - |
| KFV36_RS10975 (KFV36_10985) | 2250088..2250372 | + | 285 | WP_001829635.1 | hypothetical protein | - |
| KFV36_RS10980 (KFV36_10990) | 2250396..2250620 | + | 225 | WP_001829613.1 | hypothetical protein | - |
| KFV36_RS10985 (KFV36_10995) | 2251241..2251441 | - | 201 | WP_001829681.1 | cold-shock protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2244299..2244454 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7229.94 Da Isoelectric Point: 9.7844
>T200355 WP_001829569.1 NZ_CP073827:2247734-2247922 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
Download Length: 189 bp
>T200355 NZ_CP097834:2350292-2350753 [Shigella flexneri]
TTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACTG
TGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAGAC
AACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGGAGCGCGG
AAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAAAAATTCACCCGGCATTACC
AATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCGA
CACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG
TTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACTG
TGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAGAC
AACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGGAGCGCGG
AAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAAAAATTCACCCGGCATTACC
AATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCGA
CACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 10014.05 Da Isoelectric Point: 4.5440
>AT200355 WP_002438963.1 NZ_CP073827:2247452-2247709 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
Download Length: 258 bp
>AT200355 NZ_CP097834:2349909-2350220 [Shigella flexneri]
ATGCCTGGAAAAACAGCCGCTCTATACGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA
ATGCCTGGAAAAACAGCCGCTCTATACGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0N0LUH8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U5IVM3 |