Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2032926..2033435 Replicon chromosome
Accession NZ_CP073827
Organism Staphylococcus epidermidis strain B1208538

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KFV36_RS09775 Protein ID WP_001829980.1
Coordinates 2032926..2033135 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KFV36_RS09780 Protein ID WP_001829893.1
Coordinates 2033142..2033435 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV36_RS09755 (KFV36_09765) 2028504..2029859 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KFV36_RS09760 (KFV36_09770) 2029871..2030944 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KFV36_RS09765 (KFV36_09775) 2031335..2032546 + 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KFV36_RS09770 (KFV36_09780) 2032646..2032783 - 138 WP_001829949.1 Lmo0850 family protein -
KFV36_RS09775 (KFV36_09785) 2032926..2033135 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KFV36_RS09780 (KFV36_09790) 2033142..2033435 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KFV36_RS09785 (KFV36_09795) 2033609..2035093 + 1485 WP_002457116.1 cardiolipin synthase -
KFV36_RS09790 (KFV36_09800) 2035275..2035928 + 654 WP_001829983.1 HD domain-containing protein -
KFV36_RS09795 (KFV36_09805) 2036034..2036906 - 873 WP_002458703.1 membrane protein insertase YidC -
KFV36_RS09800 (KFV36_09810) 2036995..2037633 - 639 WP_002505076.1 thiamine phosphate synthase -
KFV36_RS09805 (KFV36_09815) 2037639..2038427 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T200354 WP_001829980.1 NZ_CP073827:c2033135-2032926 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T200354 NZ_CP097834:2313353-2313571 [Shigella flexneri]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT200354 WP_001829893.1 NZ_CP073827:c2033435-2033142 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT200354 NZ_CP097834:2312953-2313327 [Shigella flexneri]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGTTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGCTCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAACGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References