Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 690511..691040 Replicon chromosome
Accession NZ_CP073824
Organism Staphylococcus epidermidis strain B1200599

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag KFV28_RS03510 Protein ID WP_001829891.1
Coordinates 690678..691040 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag KFV28_RS03505 Protein ID WP_001829931.1
Coordinates 690511..690681 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV28_RS03480 (KFV28_03480) 686336..686815 + 480 WP_063278489.1 PH domain-containing protein -
KFV28_RS03485 (KFV28_03485) 686808..688313 + 1506 WP_001829976.1 PH domain-containing protein -
KFV28_RS03490 (KFV28_03490) 688300..688809 + 510 WP_001829888.1 PH domain-containing protein -
KFV28_RS03495 (KFV28_03495) 688857..689210 + 354 WP_001829915.1 holo-ACP synthase -
KFV28_RS03500 (KFV28_03500) 689276..690424 + 1149 WP_002468951.1 alanine racemase -
KFV28_RS03505 (KFV28_03505) 690511..690681 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KFV28_RS03510 (KFV28_03510) 690678..691040 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KFV28_RS03515 (KFV28_03515) 691386..692387 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
KFV28_RS03520 (KFV28_03520) 692487..692813 + 327 WP_001829952.1 anti-sigma factor antagonist -
KFV28_RS03525 (KFV28_03525) 692815..693255 + 441 WP_063278490.1 anti-sigma B factor RsbW -
KFV28_RS03530 (KFV28_03530) 693269..694039 + 771 WP_002468952.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T200348 WP_001829891.1 NZ_CP073824:690678-691040 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T200348 NZ_CP097834:685292-685447 [Shigella flexneri]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT200348 WP_001829931.1 NZ_CP073824:690511-690681 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT200348 NZ_CP097834:c685280-685222 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References