Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 679328..679837 Replicon chromosome
Accession NZ_CP073824
Organism Staphylococcus epidermidis strain B1200599

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KFV28_RS03450 Protein ID WP_001829980.1
Coordinates 679628..679837 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KFV28_RS03445 Protein ID WP_001829893.1
Coordinates 679328..679621 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV28_RS03420 (KFV28_03420) 674336..675124 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
KFV28_RS03425 (KFV28_03425) 675130..675768 + 639 WP_002505076.1 thiamine phosphate synthase -
KFV28_RS03430 (KFV28_03430) 675857..676729 + 873 WP_002458703.1 membrane protein insertase YidC -
KFV28_RS03435 (KFV28_03435) 676835..677488 - 654 WP_001829983.1 HD domain-containing protein -
KFV28_RS03440 (KFV28_03440) 677670..679154 - 1485 WP_002457116.1 cardiolipin synthase -
KFV28_RS03445 (KFV28_03445) 679328..679621 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KFV28_RS03450 (KFV28_03450) 679628..679837 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KFV28_RS03455 (KFV28_03455) 679980..680117 + 138 WP_001829949.1 Lmo0850 family protein -
KFV28_RS03460 (KFV28_03460) 680217..681428 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KFV28_RS03465 (KFV28_03465) 681819..682892 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KFV28_RS03470 (KFV28_03470) 682904..684259 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T200347 WP_001829980.1 NZ_CP073824:679628-679837 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T200347 NZ_CP097832:167477-167959 [Shigella flexneri]
ATGGAAATAAATGTCACCGCGCCAGCATTGTTGACGGATGAGCATATACTTCAGCCATTTGACTGTGGAAATGAGGTGCT
AAGTAACTGGTTACGTGGTCGGGCTATGAAAAACCAGATGCTCAATGCTTCTCGCACGTTCGTTATTTGCTTGGAGGATA
CTTTACGTATTGTGGGATACTACTCATTAGCTACTGGTTCCGTCACTCATGCCGAGCTTGGTCGCAGTTTGCGGCATAAC
ATGCCCAATCCTGTCCCTGTTGTTCTGTTAGGGCGTCTGGCTGTTGATGTTTGTACCCAGGGGCATGGTTTCGGTAAATG
GCTACTAAGTGATGCCATTCACCGGGTTGTCAATCTGGCTGATCAGGTTGGCATTAAGGCTGTTATGGTACATGCAATTG
ATGATGACGCCAGAGCATTTTATGAGCGTTTTGGTTTTGTTCAGTCAGTTGTGGCACCTAATACCTTGTTTTATAAAGTC
TGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT200347 WP_001829893.1 NZ_CP073824:679328-679621 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT200347 NZ_CP097832:167184-167486 [Shigella flexneri]
ATGGAGGTTTTTATGTCTACAGCTGCAAGCGTCCGTAAAACACCGCGAGAACATCAGATTAACATCCGGGCAACTGATGA
GGAACGAGCCGTTATTGATTATGCTGCGAGCTTGGTCAATAAGAACCGTACCGATTTCATCATGGAACTGGCGTACCAGG
AAGCTAAAAACATTATCCTGGATCAACGTTTATTTGTGCTGGATAACGAACGTTATGATTCGTTTATTACGCAACTGGAA
GCTCCTGTGCAGAATGCAGAAGGGCGTGAACGTCTGATGGCGGTAAAGCCTGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References