Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 464841..465311 Replicon chromosome
Accession NZ_CP073824
Organism Staphylococcus epidermidis strain B1200599

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag KFV28_RS02270 Protein ID WP_001829569.1
Coordinates 464841..465029 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag KFV28_RS13330 Protein ID WP_002438963.1
Coordinates 465054..465311 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV28_RS02240 (KFV28_02240) 461322..461522 + 201 WP_001829681.1 cold-shock protein -
KFV28_RS02245 (KFV28_02245) 462143..462367 - 225 WP_001829613.1 hypothetical protein -
KFV28_RS02250 (KFV28_02250) 462391..462675 - 285 WP_001829635.1 hypothetical protein -
KFV28_RS02255 (KFV28_02255) 462774..463520 - 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
KFV28_RS02260 (KFV28_02260) 463804..464037 + 234 WP_001829664.1 hypothetical protein -
KFV28_RS02265 (KFV28_02265) 464097..464651 - 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
KFV28_RS02270 (KFV28_02270) 464841..465029 - 189 WP_001829569.1 hypothetical protein Toxin
KFV28_RS13330 465054..465311 - 258 WP_002438963.1 hypothetical protein Antitoxin
KFV28_RS02275 (KFV28_02275) 465720..465923 + 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
KFV28_RS02280 (KFV28_02280) 465915..466151 - 237 WP_002457224.1 hypothetical protein -
KFV28_RS02285 (KFV28_02285) 466365..466952 + 588 WP_001829615.1 histidine phosphatase family protein -
KFV28_RS02290 (KFV28_02290) 467223..467723 - 501 WP_001829623.1 GNAT family N-acetyltransferase -
KFV28_RS02295 (KFV28_02295) 468327..468464 + 138 WP_162161215.1 hypothetical protein -
KFV28_RS02300 (KFV28_02300) 468648..469070 - 423 WP_002457221.1 organic hydroperoxide resistance protein -
KFV28_RS02305 (KFV28_02305) 469231..469947 + 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 446629..470570 23941
- flank IS/Tn - - 468309..468464 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(12-88)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T200346 WP_001829569.1 NZ_CP073824:c465029-464841 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T200346 NZ_CP097832:125620-126105 [Shigella flexneri]
ATGGGATGTGTAACTGCACCAGAACCTTTATCCTCATTTCATCAGGTCGCTGAATTTGTCAGCAGTGAAGCTGTACTTGA
TGACTGGTTAAAGCAGAAGGAGCTAAAAAATCAGGCAATCGGAGCCACCCGGACTTTTGTTGTATGCAGAAAAGGTACGC
AACAAATAGTCGGTTTTTACTCACTGGCCACTGGTAGTGTCAATCATACAGAAGCTACAGGTAACCTTCGGCGCAATATG
CCAGACCCCATTCCTGTAATTATACTTGCACGCCTGGCTGTAGATGTGTCATTTCGAGGAAAAGGGCTTGGCGCGGATTT
ACTTCATGATGCAGTTCGTCGTTGTTACAGGGTTGCCGAAAATATCGGTGTGCGTGCAATTATGGTTCATGCGCTTACGG
AAAACGCAAAACAGTTTTATATTCATCATGGTTTTAAGCCATCAAAAACTCAGGTGCAAACATTGTTTCTTAAACTCCCT
CAATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT200346 WP_002438963.1 NZ_CP073824:c465311-465054 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT200346 NZ_CP097832:125348-125632 [Shigella flexneri]
ATGATATACGGAGGCTTTATGAAATCAGGTGTTCAGCTCAATCTCAGAGCAAGAGAATCACAGCGGATACTCATTGATGC
TGCTGCAGAAATTCTTCATAAGTCGCGTACAGATTTCATTCTGGAAATGGCCTGTAAAGCTGCTGAAGATGTTATTCTCG
ACCGGCGGGTGTTTAATTTTAATGACAGGCAATATGAAGAGTTCATTGAAATGCTTGATGCTCCGGTTGCAGATGATCCT
GCCATCGAAAAATTGCTGGCAAGGAAACCTCAATGGGATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References