Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 681885..682394 Replicon chromosome
Accession NZ_CP073821
Organism Staphylococcus epidermidis strain B1200343

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KFV43_RS03455 Protein ID WP_001829980.1
Coordinates 682185..682394 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KFV43_RS03450 Protein ID WP_001829893.1
Coordinates 681885..682178 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV43_RS03425 (KFV43_03425) 676893..677681 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
KFV43_RS03430 (KFV43_03430) 677687..678325 + 639 WP_002505076.1 thiamine phosphate synthase -
KFV43_RS03435 (KFV43_03435) 678414..679286 + 873 WP_002458703.1 membrane protein insertase YidC -
KFV43_RS03440 (KFV43_03440) 679392..680045 - 654 WP_001829983.1 HD domain-containing protein -
KFV43_RS03445 (KFV43_03445) 680227..681711 - 1485 WP_002457116.1 cardiolipin synthase -
KFV43_RS03450 (KFV43_03450) 681885..682178 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KFV43_RS03455 (KFV43_03455) 682185..682394 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KFV43_RS03460 (KFV43_03460) 682537..682674 + 138 WP_001829949.1 Lmo0850 family protein -
KFV43_RS03465 (KFV43_03465) 682774..683985 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KFV43_RS03470 (KFV43_03470) 684376..685449 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KFV43_RS03475 (KFV43_03475) 685461..686816 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T200342 WP_001829980.1 NZ_CP073821:682185-682394 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T200342 NZ_CP097831:4476232-4476630 [Shigella flexneri]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT200342 WP_001829893.1 NZ_CP073821:681885-682178 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT200342 NZ_CP097831:4475936-4476229 [Shigella flexneri]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
AGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTTCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
AAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References