Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1973205..1973761 Replicon chromosome
Accession NZ_CP073820
Organism Xanthomonas oryzae strain PXO99A-gx

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag KFK26_RS09160 Protein ID WP_229002778.1
Coordinates 1973510..1973761 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A854CIX2
Locus tag KFK26_RS09155 Protein ID WP_011408759.1
Coordinates 1973205..1973483 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFK26_RS09135 (KFK26_09140) 1968322..1968879 - 558 WP_011259349.1 DNA-3-methyladenine glycosylase -
KFK26_RS09140 (KFK26_09145) 1969029..1969994 - 966 WP_109181928.1 IS1595-like element ISXo5 family transposase -
KFK26_RS09145 (KFK26_09150) 1970575..1971759 + 1185 WP_011408397.1 IS256-like element IS1113 family transposase -
KFK26_RS09150 (KFK26_09160) 1972665..1973009 + 345 WP_198912817.1 hypothetical protein -
KFK26_RS09155 (KFK26_09170) 1973205..1973483 + 279 WP_011408759.1 CopG family ribbon-helix-helix protein Antitoxin
KFK26_RS09160 (KFK26_09175) 1973510..1973761 + 252 WP_229002778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KFK26_RS09165 (KFK26_09180) 1973838..1974092 + 255 WP_198912806.1 hypothetical protein -
KFK26_RS23460 1974085..1974219 + 135 WP_011051575.1 hypothetical protein -
KFK26_RS09170 (KFK26_09185) 1974288..1974542 + 255 WP_223293127.1 hypothetical protein -
KFK26_RS09175 1974759..1974878 + 120 Protein_1776 IS3 family transposase -
KFK26_RS23465 1974847..1974975 + 129 WP_012444694.1 hypothetical protein -
KFK26_RS09180 (KFK26_09190) 1975044..1975842 + 799 WP_094187731.1 IS5 family transposase -
KFK26_RS09190 (KFK26_09200) 1976258..1976659 - 402 WP_011259345.1 H-NS family nucleoid-associated regulatory protein -
KFK26_RS09195 (KFK26_09205) 1976881..1977057 + 177 Protein_1780 DUF3606 domain-containing protein -
KFK26_RS09200 (KFK26_09215) 1977339..1977655 + 317 Protein_1781 ATP-dependent DNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 1969029..1975842 6813


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-81)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9617.95 Da        Isoelectric Point: 9.9718

>T200338 WP_229002778.1 NZ_CP073820:1973510-1973761 [Xanthomonas oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILALRHQKE
AGY

Download         Length: 252 bp

>T200338 NZ_CP097831:3516639-3516746 [Shigella flexneri]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTGCCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10826.11 Da        Isoelectric Point: 4.9736

>AT200338 WP_011408759.1 NZ_CP073820:1973205-1973483 [Xanthomonas oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Download         Length: 279 bp

>AT200338 NZ_CP097831:c3516583-3516527 [Shigella flexneri]
TCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A854CIX2

References