Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2152556..2153065 Replicon chromosome
Accession NZ_CP073819
Organism Macrococcus epidermidis strain Epi3002-OL

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KFV12_RS11515 Protein ID WP_096078043.1
Coordinates 2152556..2152918 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KFV12_RS11520 Protein ID WP_170122538.1
Coordinates 2152919..2153065 (-) Length 49 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV12_RS11490 (KFV12_11540) 2147632..2149782 - 2151 WP_111716744.1 Tex family protein -
KFV12_RS11495 (KFV12_11545) 2149863..2150630 - 768 WP_099581373.1 RNA polymerase sigma factor SigB -
KFV12_RS11500 (KFV12_11550) 2150641..2151081 - 441 WP_111716742.1 anti-sigma B factor RsbW -
KFV12_RS11505 (KFV12_11555) 2151083..2151409 - 327 WP_254256811.1 anti-sigma factor antagonist -
KFV12_RS11510 (KFV12_11560) 2151499..2152506 - 1008 WP_111716738.1 PP2C family protein-serine/threonine phosphatase -
KFV12_RS11515 (KFV12_11565) 2152556..2152918 - 363 WP_096078043.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KFV12_RS11520 (KFV12_11570) 2152919..2153065 - 147 WP_170122538.1 hypothetical protein Antitoxin
KFV12_RS11525 (KFV12_11575) 2153128..2154273 - 1146 WP_254256812.1 alanine racemase -
KFV12_RS11530 (KFV12_11580) 2154330..2154668 - 339 WP_111716735.1 holo-ACP synthase -
KFV12_RS11535 (KFV12_11585) 2154661..2155140 - 480 WP_111716733.1 PH domain-containing protein -
KFV12_RS11540 (KFV12_11590) 2155133..2156638 - 1506 WP_239243284.1 PH domain-containing protein -
KFV12_RS11545 (KFV12_11595) 2156625..2157104 - 480 WP_170122537.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13231.30 Da        Isoelectric Point: 7.3168

>T200336 WP_096078043.1 NZ_CP073819:c2152918-2152556 [Macrococcus epidermidis]
MKRGDVYLADLSPVKGSEQGGKRPVVIIQNDIGNKYSPTVIVAAITAKINKSKIPTHVEIGKTNHHLDKDSVILLEQIRT
IDKNRLIEKLTYLPKEKMEEVDAALAISLNLSIDDSETLG

Download         Length: 363 bp

>T200336 NZ_CP097831:c3213565-3213278 [Shigella flexneri]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 49 a.a.        Molecular weight: 5546.16 Da        Isoelectric Point: 3.7510

>AT200336 WP_170122538.1 NZ_CP073819:c2153065-2152919 [Macrococcus epidermidis]
MSKLQEQQLIEGYQSMAEINLLIASEHYLLECEVYDNVDHMSVQTDGE

Download         Length: 147 bp

>AT200336 NZ_CP097831:c3213804-3213565 [Shigella flexneri]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References