Detailed information of TA system TA200335

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1951951..1952719
• Replicon: chromosome
• Accession: NZ_CP073819
• Organism: Macrococcus epidermidis strain Epi3002-OL

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: KFV12_RS10315
• Protein ID: WP_165958672.1
• Coordinates: 1951951..1952094 (-)
• Length: 48 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: KFV12_RS10320
• Protein ID: WP_111716270.1
• Coordinates: 1952108..1952719 (-)
• Length: 204 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFV12_RS10305 (KFV12_10355)	1948892..1950424	-	1533	WP_111716273.1	exopolyphosphatase	-
KFV12_RS10310 (KFV12_10360)	1950455..1951840	-	1386	WP_111716271.1	class II fumarate hydratase	-
KFV12_RS10315 (KFV12_10365)	1951951..1952094	-	144	WP_165958672.1	SAS053 family protein	Toxin
KFV12_RS10320 (KFV12_10370)	1952108..1952719	-	612	WP_111716270.1	glucosamine-6-phosphate isomerase	Antitoxin
KFV12_RS10325 (KFV12_10375)	1953048..1953785	-	738	WP_254256721.1	oxygen-insensitive NADPH nitroreductase	-
KFV12_RS10330 (KFV12_10380)	1953798..1954271	-	474	WP_096075976.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KFV12_RS10335 (KFV12_10385)	1954272..1955396	-	1125	WP_239243194.1	tRNA epoxyqueuosine(34) reductase QueG	-
KFV12_RS10340 (KFV12_10390)	1955550..1956272	-	723	WP_111716265.1	amino acid ABC transporter ATP-binding protein	-
KFV12_RS10345 (KFV12_10395)	1956265..1957671	-	1407	WP_254257654.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5413.64 Da
• Isoelectric Point: 3.6118

>T200335 WP_165958672.1 NZ_CP073819:c1952094-1951951 [Macrococcus epidermidis]
MSTSHDNKNEMVTDFDDVVELGKEMEQISEQNAEAREEGQEQEDDPQ

Nucleotide

• Length: 144 bp

>T200335 NZ_CP097831:2905255-2905358 [Shigella flexneri]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin

Protein

• Length: 204 a.a.
• Molecular weight: 22470.37 Da
• Isoelectric Point: 5.1301

>AT200335 WP_111716270.1 NZ_CP073819:c1952719-1952108 [Macrococcus epidermidis]
MGMNFKIFEDKLTVSNYVADLFRKQMSNNPTSIIATALGDEAGHVIAELKADTARNPVETSQIHIFDYDKIRGDYGTVGI
VDKQYHEATGKDIMELIKDEAKTKENKGKLTTLFATITQDGSVGYKEINQDNDKGLRSAREIIIVLTGADKASIVEKLYN
AEAGGNFEAANLKTHRMVNVILDDAAAAGLPQDIREYYFQKFA

Nucleotide

• Length: 612 bp

>AT200335 NZ_CP097831:c2905359-2905125 [Shigella flexneri]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGCGGTGCTCATCAGCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT