Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE(toxin) |
| Location | 1172631..1173118 | Replicon | chromosome |
| Accession | NZ_CP073808 | ||
| Organism | Macrococcus canis strain IMD0709 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | KFV10_RS05975 | Protein ID | WP_254253292.1 |
| Coordinates | 1172882..1173118 (+) | Length | 79 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | KFV10_RS05970 | Protein ID | WP_086042497.1 |
| Coordinates | 1172631..1172855 (+) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV10_RS05925 (KFV10_05915) | 1167798..1168256 | + | 459 | WP_254253286.1 | NUDIX domain-containing protein | - |
| KFV10_RS05930 (KFV10_05920) | 1168352..1168603 | + | 252 | WP_254253287.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| KFV10_RS05935 (KFV10_05925) | 1168603..1168863 | + | 261 | WP_236365518.1 | Txe/YoeB family addiction module toxin | - |
| KFV10_RS05940 (KFV10_05930) | 1168864..1169313 | - | 450 | WP_086042491.1 | GNAT family N-acetyltransferase | - |
| KFV10_RS05945 (KFV10_05935) | 1169531..1170421 | + | 891 | WP_254253288.1 | phosphotransferase | - |
| KFV10_RS05950 (KFV10_05940) | 1170545..1171030 | + | 486 | WP_254253289.1 | NUDIX domain-containing protein | - |
| KFV10_RS05955 (KFV10_05945) | 1171036..1171797 | + | 762 | WP_254253290.1 | hypothetical protein | - |
| KFV10_RS05960 (KFV10_05950) | 1171820..1172092 | - | 273 | WP_254253291.1 | Txe/YoeB family addiction module toxin | - |
| KFV10_RS05965 (KFV10_05955) | 1172085..1172342 | - | 258 | WP_086042496.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| KFV10_RS05970 (KFV10_05960) | 1172631..1172855 | + | 225 | WP_086042497.1 | DUF6290 family protein | Antitoxin |
| KFV10_RS05975 (KFV10_05965) | 1172882..1173118 | + | 237 | WP_254253292.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KFV10_RS05980 (KFV10_05970) | 1173229..1173597 | + | 369 | WP_236365523.1 | GntR family transcriptional regulator | - |
| KFV10_RS05985 (KFV10_05975) | 1173597..1174697 | + | 1101 | WP_254253293.1 | DUF1648 domain-containing protein | - |
| KFV10_RS05990 (KFV10_05980) | 1175139..1176401 | + | 1263 | WP_254254439.1 | Y-family DNA polymerase | - |
| KFV10_RS05995 (KFV10_05985) | 1176554..1176742 | + | 189 | WP_254253294.1 | hypothetical protein | - |
| KFV10_RS06000 (KFV10_05990) | 1177001..1178041 | + | 1041 | WP_254253295.1 | M42 family metallopeptidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 79 a.a. Molecular weight: 9257.83 Da Isoelectric Point: 10.7716
>T200331 WP_254253292.1 NZ_CP073808:1172882-1173118 [Macrococcus canis]
VIKQLRKMDAQSSRLLLQWINKNIVHCEDPRSSGKALTGNYSGFWRYRVGQFRIITKIEDDKLIILVISIDHRKNIYR
VIKQLRKMDAQSSRLLLQWINKNIVHCEDPRSSGKALTGNYSGFWRYRVGQFRIITKIEDDKLIILVISIDHRKNIYR
Download Length: 237 bp
>T200331 NZ_CP097831:1236257-1236532 [Shigella flexneri]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGAAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
TGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGAAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
TGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8722.87 Da Isoelectric Point: 4.2805
>AT200331 WP_086042497.1 NZ_CP073808:1172631-1172855 [Macrococcus canis]
MATITIRVSEDEKNFLKYMSEFMNLSLTDLIKNYTIEDLEDLFDTHVADKAYIEWSKNKQTVSHNDVMQEFGLL
MATITIRVSEDEKNFLKYMSEFMNLSLTDLIKNYTIEDLEDLFDTHVADKAYIEWSKNKQTVSHNDVMQEFGLL
Download Length: 225 bp
>AT200331 NZ_CP097831:1236529-1236888 [Shigella flexneri]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGTATTCAGGGGCTGCAAAAAGAAGGAG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGTATTCAGGGGCTGCAAAAAGAAGGAG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|