Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2042681..2043172 Replicon chromosome
Accession NZ_CP073805
Organism Macrococcus canis strain Epi3241-OR

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KFV08_RS10725 Protein ID WP_138072443.1
Coordinates 2042681..2043031 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KFV08_RS10730 Protein ID WP_138072445.1
Coordinates 2043032..2043172 (-) Length 47 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV08_RS10700 (KFV08_10700) 2037789..2039924 - 2136 WP_252456018.1 Tex family protein -
KFV08_RS10705 (KFV08_10705) 2040001..2040768 - 768 WP_133420462.1 RNA polymerase sigma factor SigB -
KFV08_RS10710 (KFV08_10710) 2040773..2041216 - 444 WP_086043352.1 anti-sigma B factor RsbW -
KFV08_RS10715 (KFV08_10715) 2041221..2041544 - 324 WP_086043353.1 anti-sigma factor antagonist -
KFV08_RS10720 (KFV08_10720) 2041625..2042632 - 1008 WP_138072441.1 PP2C family protein-serine/threonine phosphatase -
KFV08_RS10725 (KFV08_10725) 2042681..2043031 - 351 WP_138072443.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KFV08_RS10730 (KFV08_10730) 2043032..2043172 - 141 WP_138072445.1 antitoxin MazE Antitoxin
KFV08_RS10735 (KFV08_10735) 2043234..2044376 - 1143 WP_252456019.1 alanine racemase -
KFV08_RS10740 (KFV08_10740) 2044410..2044757 - 348 WP_252456020.1 holo-ACP synthase -
KFV08_RS10745 (KFV08_10745) 2044699..2045220 - 522 WP_252456021.1 PH domain-containing protein -
KFV08_RS10750 (KFV08_10750) 2045204..2046715 - 1512 WP_252456022.1 PH domain-containing protein -
KFV08_RS10755 (KFV08_10755) 2046705..2047181 - 477 WP_252456023.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12750.96 Da        Isoelectric Point: 9.7528

>T200328 WP_138072443.1 NZ_CP073805:c2043031-2042681 [Macrococcus canis]
MKRGDVYLADLSPVKGSEQGGKRPVVIIQNNIGNKHSPTVIVAAITAKINKAKIPTHVEIGKTAYHLEKDSVILLEQIRT
IDKYRLIDHLTVLDKAKMKEVDVALLISLGLSIDSE

Download         Length: 351 bp

>T200328 NZ_CP097831:1155519-1155626 [Shigella flexneri]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAG

Antitoxin


Download         Length: 47 a.a.        Molecular weight: 5319.89 Da        Isoelectric Point: 3.8301

>AT200328 WP_138072445.1 NZ_CP073805:c2043172-2043032 [Macrococcus canis]
MSQKLEQMLIEGYQSMAEINLSIASEHYILECEVNDNHQTYTIDGE

Download         Length: 141 bp

>AT200328 NZ_CP097831:c1155470-1155404 [Shigella flexneri]
GTCTAGGTTCAAGATTAGCCCCCGTTATGTTGTCAGGTACATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References