Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1816395..1816886 Replicon chromosome
Accession NZ_CP073801
Organism Macrococcus caseolyticus strain 19Msa198

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KFV06_RS09430 Protein ID WP_086039219.1
Coordinates 1816395..1816745 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KFV06_RS09435 Protein ID WP_101031708.1
Coordinates 1816746..1816886 (-) Length 47 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV06_RS09405 (KFV06_09410) 1811499..1813634 - 2136 WP_101039895.1 Tex family protein -
KFV06_RS09410 (KFV06_09415) 1813711..1814478 - 768 WP_101042186.1 RNA polymerase sigma factor SigB -
KFV06_RS09415 (KFV06_09420) 1814483..1814926 - 444 WP_015912229.1 anti-sigma B factor RsbW -
KFV06_RS09420 (KFV06_09425) 1814931..1815254 - 324 WP_101144312.1 anti-sigma factor antagonist -
KFV06_RS09425 (KFV06_09430) 1815339..1816346 - 1008 WP_101035469.1 PP2C family protein-serine/threonine phosphatase -
KFV06_RS09430 (KFV06_09435) 1816395..1816745 - 351 WP_086039219.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KFV06_RS09435 (KFV06_09440) 1816746..1816886 - 141 WP_101031708.1 antitoxin MazE Antitoxin
KFV06_RS09440 (KFV06_09445) 1816947..1818089 - 1143 WP_086039220.1 alanine racemase -
KFV06_RS09445 (KFV06_09450) 1818115..1818471 - 357 WP_086039221.1 holo-ACP synthase -
KFV06_RS09450 (KFV06_09455) 1818413..1818934 - 522 WP_015912235.1 PH domain-containing protein -
KFV06_RS09455 (KFV06_09460) 1818918..1820429 - 1512 WP_086039222.1 PH domain-containing protein -
KFV06_RS09460 (KFV06_09465) 1820419..1820895 - 477 WP_041636191.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12706.90 Da        Isoelectric Point: 10.1643

>T200322 WP_086039219.1 NZ_CP073801:c1816745-1816395 [Macrococcus caseolyticus]
MKRGDVFLADLSPVKGSEQGGKRPVVIIQNNIGNKYSPTVIVAAITAKINKAKIPTHVEIGKATHRLEKDSVILLEQIRT
IDKNRLIDHLTVLDKAKMKEVDTALIISLGLSIDSE

Download         Length: 351 bp

>T200322 NZ_CP097828:c4485378-4485275 [Shigella flexneri]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 47 a.a.        Molecular weight: 5326.88 Da        Isoelectric Point: 3.8301

>AT200322 WP_101031708.1 NZ_CP073801:c1816886-1816746 [Macrococcus caseolyticus]
MSQKLEQMLIEGYQSMAEINLSIASEHYVLECEVTDNHQTYTFDGE

Download         Length: 141 bp

>AT200322 NZ_CP097828:4485274-4485508 [Shigella flexneri]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGCGGTGCTCATCAGCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References