Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2062850..2063341 Replicon chromosome
Accession NZ_CP073799
Organism Macrococcus canis strain Epi0089

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KFV05_RS10785 Protein ID WP_086043355.1
Coordinates 2062850..2063200 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KFV05_RS10790 Protein ID WP_101495293.1
Coordinates 2063201..2063341 (-) Length 47 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV05_RS10765 (KFV05_10775) 2060170..2060937 - 768 WP_133420462.1 RNA polymerase sigma factor SigB -
KFV05_RS10770 (KFV05_10780) 2060942..2061385 - 444 WP_086043352.1 anti-sigma B factor RsbW -
KFV05_RS10775 (KFV05_10785) 2061390..2061713 - 324 WP_086043353.1 anti-sigma factor antagonist -
KFV05_RS10780 (KFV05_10790) 2061794..2062801 - 1008 WP_086043354.1 PP2C family protein-serine/threonine phosphatase -
KFV05_RS10785 (KFV05_10795) 2062850..2063200 - 351 WP_086043355.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KFV05_RS10790 (KFV05_10800) 2063201..2063341 - 141 WP_101495293.1 antitoxin MazE Antitoxin
KFV05_RS10795 (KFV05_10805) 2063403..2064545 - 1143 WP_254246221.1 alanine racemase -
KFV05_RS10800 (KFV05_10810) 2064571..2064927 - 357 WP_164953884.1 holo-ACP synthase -
KFV05_RS10805 (KFV05_10815) 2064869..2065390 - 522 WP_252456021.1 PH domain-containing protein -
KFV05_RS10810 (KFV05_10820) 2065374..2066885 - 1512 WP_254246222.1 PH domain-containing protein -
KFV05_RS10815 (KFV05_10825) 2066875..2067351 - 477 WP_254246223.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12705.88 Da        Isoelectric Point: 9.9423

>T200320 WP_086043355.1 NZ_CP073799:c2063200-2062850 [Macrococcus canis]
MKRGDVYLADLSPVKGSEQGGKRPVVIIQNNIGNKHSPTVIVAAITAKINKAKIPTHVEIGKTTHHLEKDSVILLEQIRT
IDKNRLIDHLTVLDKAKMKEVDVALLISLGLSIDSE

Download         Length: 351 bp

>T200320 NZ_CP097828:4003651-4003806 [Shigella flexneri]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 47 a.a.        Molecular weight: 5319.89 Da        Isoelectric Point: 3.8301

>AT200320 WP_101495293.1 NZ_CP073799:c2063341-2063201 [Macrococcus canis]
MSQKLEQMLIEGYQSMAEINLSIASEHYILECEVNDNHQTYTLDGE

Download         Length: 141 bp

>AT200320 NZ_CP097828:c4003639-4003581 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References