Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2189595..2190226 Replicon chromosome
Accession NZ_CP073797
Organism Dactylosporangium matsuzakiense strain NRRL B-16293

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag Dmats_RS09620 Protein ID WP_261963473.1
Coordinates 2189595..2190020 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag Dmats_RS09625 Protein ID WP_261963474.1
Coordinates 2190017..2190226 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Dmats_RS09605 (Dmats_09560) 2185901..2187361 + 1461 WP_223102175.1 argininosuccinate synthase -
Dmats_RS09610 (Dmats_09565) 2187464..2188171 - 708 WP_261963471.1 uracil-DNA glycosylase -
Dmats_RS09615 (Dmats_09570) 2188182..2189537 - 1356 WP_261963472.1 MFS transporter -
Dmats_RS09620 (Dmats_09575) 2189595..2190020 - 426 WP_261963473.1 PIN domain nuclease Toxin
Dmats_RS09625 (Dmats_09580) 2190017..2190226 - 210 WP_261963474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
Dmats_RS09630 (Dmats_09585) 2190288..2190884 - 597 WP_261963475.1 MBL fold metallo-hydrolase -
Dmats_RS09635 (Dmats_09590) 2190881..2191549 - 669 WP_261963476.1 maleylpyruvate isomerase family mycothiol-dependent enzyme -
Dmats_RS09640 (Dmats_09595) 2191559..2191993 - 435 WP_261963477.1 hypothetical protein -
Dmats_RS09645 (Dmats_09600) 2192086..2193120 + 1035 WP_261963478.1 ribosome small subunit-dependent GTPase A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(4-34)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15500.81 Da        Isoelectric Point: 5.5353

>T200311 WP_261963473.1 NZ_CP073797:c2190020-2189595 [Dactylosporangium matsuzakiense]
MTPVRFLVDTSALVRLLRNHQLRVRWEPQITAGVIGICPITELELLHSARSKTDREEWLELLNATFAWVPMPEQIFVRAT
EVQAAMTASGTHRSAGAVDLLLAATAELSGLTLVHYDHDFDEIVKTTGQAAVWLAPAGSIS

Download         Length: 426 bp

>T200311 NZ_CP097828:c1636577-1636302 [Shigella flexneri]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGAAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
TGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7408.41 Da        Isoelectric Point: 5.0323

>AT200311 WP_261963474.1 NZ_CP073797:c2190226-2190017 [Dactylosporangium matsuzakiense]
MTKVLIDIDDDALAEASALLGTKTKKDTVNTALRSTADQLRRAKALTRLAELGEAGAFDELLDKSAYRG

Download         Length: 210 bp

>AT200311 NZ_CP097828:c1636305-1635946 [Shigella flexneri]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGTATTCAGGGGCTGCAAAAAGAAGGAG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References