Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 1250418..1251391 Replicon chromosome
Accession NZ_CP073791
Organism Klebsiella pneumoniae isolate KP_NORM_BLD_2010_71621

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag KFO61_RS06025 Protein ID WP_072040111.1
Coordinates 1250418..1250825 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag KFO61_RS06030 Protein ID WP_040215292.1
Coordinates 1250822..1251391 (-) Length 190 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFO61_RS06010 (KFO61_06010) 1245712..1247439 + 1728 WP_222169305.1 hypothetical protein -
KFO61_RS06015 (KFO61_06015) 1247432..1249999 + 2568 WP_032436809.1 hypothetical protein -
KFO61_RS06020 (KFO61_06020) 1250002..1250385 + 384 WP_040215289.1 Rap1a/Tai family immunity protein -
KFO61_RS06025 (KFO61_06025) 1250418..1250825 - 408 WP_072040111.1 hypothetical protein Toxin
KFO61_RS06030 (KFO61_06030) 1250822..1251391 - 570 WP_040215292.1 Panacea domain-containing protein Antitoxin
KFO61_RS06035 (KFO61_06035) 1251560..1251823 - 264 WP_228751023.1 hypothetical protein -
KFO61_RS06040 (KFO61_06040) 1251924..1252172 - 249 WP_032410641.1 AlpA family phage regulatory protein -
KFO61_RS06045 (KFO61_06045) 1252255..1252647 + 393 WP_052455502.1 KilA-N domain-containing protein -
KFO61_RS27485 1253149..1253314 - 166 Protein_1164 hypothetical protein -
KFO61_RS06050 (KFO61_06050) 1253592..1253885 + 294 WP_002892360.1 hypothetical protein -
KFO61_RS06055 (KFO61_06055) 1254281..1254682 + 402 WP_002892366.1 hydroxyisourate hydrolase -
KFO61_RS06060 (KFO61_06060) 1254761..1254931 - 171 WP_002892370.1 hypothetical protein -
KFO61_RS06065 (KFO61_06065) 1255256..1255396 + 141 WP_004142684.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1231048..1251823 20775


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-143)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15154.21 Da        Isoelectric Point: 5.9868

>T200290 WP_072040111.1 NZ_CP073791:c1250825-1250418 [Klebsiella pneumoniae]
MTQQYAPYRKGTVLAPVGGSDHLHIICNDPVHYPIHGCDCVLVVNISSVYPPPAYSDPACILHAGEHPFVFHDSFVYYED
AIVWKVPNVISREQSGELTPHADMEENVLQRVLSGFEASDFTNPKILKFYRAHCI

Download         Length: 408 bp

>T200290 NZ_CP097804:3858340-3859263 [Xanthomonas oryzae pv. oryzae]
ATGAACGAACCTGACAAGAGCAGGCGCACTGTTGCCGCGTCGGTTCGCGCCCGGCTGCTCAACAAGGCCCGCGCCGAAAG
ACTCGACTTCAACCTGCTGCTGACCCGCTACGCGCTGGAGCGCGTCCTTTACCGCCTGAGCGTTTCGGAGCAGCAGGGTC
AATTCTTGCTCAAAGGTGCGCTGCTGTTCGACATCTGGTTCGACATACCGCATCGCCCGACGCACGATGCCGACCTGCTG
GGCTTCGGCTCCACCGAGATCCCACATCTGGAAGACCTGTTCCGCAGAATCAGTCAAATCGCCAGCGATGACGGCATCGT
GTTTCAGGCCGACAGCGTGAAGGCCGCCGAAATCCGCAAGGAGGCCAACTACGCGGGCGTCCGTGTGACGATGATCGGCC
TGCTCGATGGCGCGCGCTGCACGGTGCAGATCGACATCGGTTTCGGCGACGCCGTGACGCCCGGCCCGGACAACGTGCAG
TACCCAGTCATCCTCGACGGCATGCCGCAGCCGCAACTGCGGGTCTATCCCCGCTACACCGTGGTCGCCGAAAAGCTGGA
AGCGATGGTCAAGCTCGGCATCCTCAACAGCCGGATGAAGGACTACTTCGACCTCTGGGTTCTCGCCGGACATTCCGACT
TCGACGGTGCGGTGCTGGCCACGGCCATTCGCGCCACGTTCGAGTGCAGGGGTACGGCCATCCCACCCGGCGCGCCGCTG
GGCCTCACCGATGAGTTCGGCCTGGACGAGCAGAAGACAAAGCAGTGGCAGGCGTTCCTGCGCAAGAACACCTTGGAGCC
GATGCCGCTGACCACGGTGATCGAAGCGCTGCGCGAATTCGTGCTGCCCGTGCTGGCCGCGCTCGCGGCAGGCGAAGGTT
TCGACCGCCAGTGGCGCGCGGGCGCGGGATGGGATGCGGCCTGA

Antitoxin


Download         Length: 190 a.a.        Molecular weight: 21591.42 Da        Isoelectric Point: 4.9915

>AT200290 WP_040215292.1 NZ_CP073791:c1251391-1250822 [Klebsiella pneumoniae]
MYSESKTAQMAGYLLLKRGGRMAYIKLMKLLYLADREYMITYGDSMTGDRAVSMNNGPVLSRTYDLLKSGSPEEESPWDD
WIAGEADFEVSLKKRVNGLDDDDAFDELSKANKRILDKVFDEYGQYKRFELCDLTHRVCAEWQNPHGSSVPISPKDILMA
GGKSESEADELIRHMRERDALKQFSRQLA

Download         Length: 570 bp

>AT200290 NZ_CP097804:3857744-3858343 [Xanthomonas oryzae pv. oryzae]
ATGGACACGACCGTCGACAAGCTGCTGGAGCTGGTGCGCACGCGGGGACTTCTGCGCCCGCACGATCTGGCCCCACTGGG
CATCCCACGGGTGGCCCTGACGCGGGCCGTTCGGCGCGGGCAACTGGAGCGCGTCGGGCGCGGCCTGTACGGCCTGGTGG
CGCGTCCGGTGTCGGCCCACGGCACGCTGGCCGAAGTCGCGCGCCGCGTGCCCAAGGGCGTGGTCTGCCTGCTGTCGGCG
CTGCGCGTCCACGACCTGACGACCCAGGCCCCGTTCGAGGTGTGGCTGGCCATCGACAACAAGGCCGCTGCCCCGAAGCT
GGACTACCCGCCGCTACGTCTCGTGCGCTTCTCCGGGCCGGCGCTGAGCGAGGGCGTCGAGGAACACGTTGTTGATGGTG
TGCCCGTCCACGTGACCAGCGTCGCCAAGACCGTGGCCGACTGCTTCAAGTACCGCAACAAGATCGGCATCGACGTGGCG
CTGGAAGCGCTGCGCGAGGCGTGGGTTGCCCGGCGCATGACCAGCGACGAGATCTGGCACTACGCCAAGATCGACCGCGT
CGCCAACGTGATGCGTCCCTATCTGGAGAGCCTGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References