Detailed information of TA system TA200283

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4882010..4883691
• Replicon: chromosome
• Accession: NZ_CP073788
• Organism: Klebsiella pneumoniae isolate KP_NORM_BLD_2015_115359

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: KFO62_RS23670
• Protein ID: WP_004146663.1
• Coordinates: 4882010..4882927 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: KFO62_RS23675
• Protein ID: WP_004177809.1
• Coordinates: 4882933..4883691 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFO62_RS23650 (4877316)	4877316..4878836	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
KFO62_RS23655 (4878833)	4878833..4879831	+	999	WP_002885172.1	ribose ABC transporter permease	-
KFO62_RS23660 (4879862)	4879862..4880803	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
KFO62_RS23665 (4880878)	4880878..4881885	+	1008	WP_222253513.1	carbohydrate kinase family protein	-
KFO62_RS23670 (4882010)	4882010..4882927	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KFO62_RS23675 (4882933)	4882933..4883691	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
KFO62_RS23680 (4883777)	4883777..4884505	-	729	WP_002885152.1	response regulator transcription factor	-
KFO62_RS23685 (4884778)	4884778..4886925	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
KFO62_RS23690 (4887387)	4887387..4888073	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T200283 WP_004146663.1 NZ_CP073788:c4882927-4882010 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T200283 NZ_CP097799:1125680-1125970 [Pasteurella multocida]
ATGAGTAAAAAAGTAGAATTAAAACCATTTGATATTGCTGAACATCTAGATAGTGAAGAAATGATTGCGGCATATTTAAG
TGAAGTTTTAGAAACAGGTGATACTAATGAATTTATTTCTGCGCTAGGTGATGTCGCAAGAGCAAGAGGAATGACGGAGT
TAGCAGCAAAAACAGGGCTGGGAAGAGAAAGCCTCTATAAAACATTATCACACGGAAGTAAGCCACGTTTTGATACTATA
ATGAAAATTACGCAAGCACTAGGTATTAAACTTGTCCCCATGCACATCTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT200283 WP_004177809.1 NZ_CP073788:c4883691-4882933 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT200283 NZ_CP097799:1125369-1125683 [Pasteurella multocida]
ATGCTCGATGTAATTGAAACAACAGTATTTAATAAATGGCTTAAAGAGTTAAAGGATTTGTCGGCTAAGGCGGCTATTCT
TGCTCGTATTAGTCGTGCTAAAAGTGGTAATTTTGGCGATCATAAATCAGTTGGTGATGGTTTGTATGAAATGCGAATAA
TGAAAGGAGCTGGTTATAGGGTTTATTATGCACAATACAAAGATGTAACCTATTTACTAATTTGTGGCGGTGATAAATCT
ACTCAGAAAGCAGATATCGCTAAAGCAAAAGCATTATGGGAAGAGATTAAGCAGAAAGAGGAGCTAAATGTATGA

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: A6TH05