Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4723586..4724102 Replicon chromosome
Accession NZ_CP073788
Organism Klebsiella pneumoniae isolate KP_NORM_BLD_2015_115359

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag KFO62_RS22865 Protein ID WP_009486548.1
Coordinates 4723586..4723870 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KFO62_RS22870 Protein ID WP_002886901.1
Coordinates 4723860..4724102 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFO62_RS22840 (4719003) 4719003..4719266 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
KFO62_RS22845 (4719396) 4719396..4719569 + 174 WP_002886906.1 hypothetical protein -
KFO62_RS22850 (4719572) 4719572..4720315 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KFO62_RS22855 (4720672) 4720672..4722810 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
KFO62_RS22860 (4723118) 4723118..4723582 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KFO62_RS22865 (4723586) 4723586..4723870 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KFO62_RS22870 (4723860) 4723860..4724102 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KFO62_RS22875 (4724180) 4724180..4726090 - 1911 WP_009486549.1 PRD domain-containing protein -
KFO62_RS22880 (4726113) 4726113..4727267 - 1155 WP_020316350.1 lactonase family protein -
KFO62_RS22885 (4727334) 4727334..4728074 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T200282 WP_009486548.1 NZ_CP073788:c4723870-4723586 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T200282 NZ_CP097799:1125369-1125683 [Pasteurella multocida]
ATGCTCGATGTAATTGAAACAACAGTATTTAATAAATGGCTTAAAGAGTTAAAGGATTTGTCGGCTAAGGCGGCTATTCT
TGCTCGTATTAGTCGTGCTAAAAGTGGTAATTTTGGCGATCATAAATCAGTTGGTGATGGTTTGTATGAAATGCGAATAA
TGAAAGGAGCTGGTTATAGGGTTTATTATGCACAATACAAAGATGTAACCTATTTACTAATTTGTGGCGGTGATAAATCT
ACTCAGAAAGCAGATATCGCTAAAGCAAAAGCATTATGGGAAGAGATTAAGCAGAAAGAGGAGCTAAATGTATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT200282 WP_002886901.1 NZ_CP073788:c4724102-4723860 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT200282 NZ_CP097799:1125680-1125970 [Pasteurella multocida]
ATGAGTAAAAAAGTAGAATTAAAACCATTTGATATTGCTGAACATCTAGATAGTGAAGAAATGATTGCGGCATATTTAAG
TGAAGTTTTAGAAACAGGTGATACTAATGAATTTATTTCTGCGCTAGGTGATGTCGCAAGAGCAAGAGGAATGACGGAGT
TAGCAGCAAAAACAGGGCTGGGAAGAGAAAGCCTCTATAAAACATTATCACACGGAAGTAAGCCACGTTTTGATACTATA
ATGAAAATTACGCAAGCACTAGGTATTAAACTTGTCCCCATGCACATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References