Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2645576..2647164 Replicon chromosome
Accession NZ_CP073788
Organism Klebsiella pneumoniae isolate KP_NORM_BLD_2015_115359

Toxin (Protein)


Gene name hipA Uniprot ID A0A486MZ73
Locus tag KFO62_RS12795 Protein ID WP_009485244.1
Coordinates 2645576..2646898 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag KFO62_RS12800 Protein ID WP_002904790.1
Coordinates 2646898..2647164 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFO62_RS12780 (2640632) 2640632..2643133 + 2502 WP_009485242.1 fimbria/pilus outer membrane usher protein -
KFO62_RS12785 (2643121) 2643121..2644125 + 1005 WP_009485243.1 fimbrial protein -
KFO62_RS12790 (2644267) 2644267..2645559 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
KFO62_RS12795 (2645576) 2645576..2646898 - 1323 WP_009485244.1 type II toxin-antitoxin system HipA family toxin Toxin
KFO62_RS12800 (2646898) 2646898..2647164 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KFO62_RS12805 (2647430) 2647430..2647756 - 327 WP_009485245.1 hydroxyisourate hydrolase -
KFO62_RS12810 (2647753) 2647753..2648253 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
KFO62_RS12815 (2648231) 2648231..2649610 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
KFO62_RS12820 (2649956) 2649956..2651110 + 1155 WP_009485247.1 FAD-dependent urate hydroxylase HpxO -
KFO62_RS12825 (2651091) 2651091..2652014 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49157.50 Da        Isoelectric Point: 7.5062

>T200279 WP_009485244.1 NZ_CP073788:c2646898-2645576 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPICEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T200279 NZ_CP097797:1674111-1674407 [Pasteurella multocida]
ATGGAACAATTAAAAGATTTTGATATAGCAGAACATTTAACAACAGAAGAAGAAATCCGACTTTATCTTAATGAAATTTT
ACAAGAAGATAATATTGAATTGATTCTCTCCGCACTTGGCGATATTGCAAGGGCTAGAAATATAAGCCAAATCTCTCGAG
AAACTGGAATTAGTAGAGAAGGGCTTTATAAGGCATTATCTGGAAAAGGAAATCCGACCTTTGCAACAGTCCTTAAAGTG
ATGAAGGCTTTGAATTTACAGTTTGAAGTTAAAGTAAATAACGTTATTCATGCTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT200279 WP_002904790.1 NZ_CP073788:c2647164-2646898 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT200279 NZ_CP097797:1673810-1674109 [Pasteurella multocida]
ATGACAATTCGAATTAAAACAACTGAGCGCTTTGATTCTTGGCTGAGAAAGCTTAAAAATCCTCGCGCAAAGATGAAAAT
TAATGCGCGTATTAAGCGGTTACAATTCGGAAATTTTGGTGACTTAAAAACTGTTAATGATGGCATTTTTGAAATGCGTA
TAGATGAAGGGCAGGGGTATAGAATTTATTTAAAAAATAACAATAGTGTGGTGGTTATATTGTTGTGTGGTGGTGATAAA
TCAACACAAAACAAAGATATTAAATTAGCAAAACAAATTGCAGAAGAATTGGGGGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486MZ73

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References