Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4656819..4657335 Replicon chromosome
Accession NZ_CP073783
Organism Klebsiella pneumoniae isolate KP_NORM_BLD_2014_96855

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag KFO63_RS22335 Protein ID WP_009486548.1
Coordinates 4656819..4657103 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A331AB37
Locus tag KFO63_RS22340 Protein ID WP_019704689.1
Coordinates 4657093..4657335 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFO63_RS22310 (KFO63_22320) 4652215..4652478 - 264 WP_020802733.1 PTS sugar transporter subunit IIB -
KFO63_RS22315 (KFO63_22325) 4652608..4652721 + 114 Protein_4376 hypothetical protein -
KFO63_RS22320 (KFO63_22330) 4652784..4653527 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KFO63_RS22325 (KFO63_22335) 4653884..4656022 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KFO63_RS22330 (KFO63_22340) 4656351..4656815 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KFO63_RS22335 (KFO63_22345) 4656819..4657103 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KFO63_RS22340 (KFO63_22350) 4657093..4657335 - 243 WP_019704689.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KFO63_RS22345 (KFO63_22355) 4657413..4659323 - 1911 WP_004152270.1 PRD domain-containing protein -
KFO63_RS22350 (KFO63_22360) 4659346..4660500 - 1155 WP_002886900.1 lactonase family protein -
KFO63_RS22355 (KFO63_22365) 4660567..4661307 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T200262 WP_009486548.1 NZ_CP073783:c4657103-4656819 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T200262 NZ_CP097778:1459659-1460009 [Paenibacillus polymyxa]
TTGATCGTAAAGCGCGGCGACGTTTTTTTTGCAGACCTTTCACCCGTAGTCGGTTCCGAGCAAGGTGGCGTCAGACCTGT
GCTGATCATTCAAAATGATATCGGCAACCGGTTTAGTCCTACTGTGATCGTAGCAGCTATCACCGCCCAGATTCAGAAGG
CGAAGCTGCCTACACACGTGGAAATCGACGCGGCGACGCATGGCTTTGATCGTGATTCTGTTGTTCTTCTGGAGCAAATT
CGGACGATCGACAAGCAAAGGCTTACCGACAAAATCACCCATTTAGATGAAGAAACCATGCGCAAAGTGAGCGATTCGCT
ACAAATCAGTCTCGGTTTGATTGATTTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9044.56 Da        Isoelectric Point: 8.5313

>AT200262 WP_019704689.1 NZ_CP073783:c4657335-4657093 [Klebsiella pneumoniae]
MATLNVRLDDKLKKQAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT200262 NZ_CP097778:1459371-1459652 [Paenibacillus polymyxa]
TTGGCCAATTTGCAGAACACCAAAAGAATAATGATCAGTTTGCCAGATCATCTCTTGCAGGAAGTGGACGGGATCGTAGC
TATGGAAAATTCCAACCGCAGTGAATTTATCAGGCAGGCCATGAAGCTGTATGTAGGCGAACGTAAAAAACGTTACATTC
GTGAAGCTATGCAGCGTGGATACATGGAAATGGCTAAAATTAACTTGACCATGGCATCCGAAGCCTTTCACGCGGAGGAA
GATGCAAACAGCACCTTGGGCCGTACAGTTAGCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A331AB37

References