Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 5387617..5388527 Replicon chromosome
Accession NZ_CP073782
Organism Klebsiella pneumoniae strain IRQBAS106c-genome

Toxin (Protein)


Gene name - Uniprot ID A0A5Q9LR54
Locus tag KFU55_RS26440 Protein ID WP_004181896.1
Coordinates 5388057..5388527 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J4RLY9
Locus tag KFU55_RS26435 Protein ID WP_004181895.1
Coordinates 5387617..5388060 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU55_RS26395 (5382810) 5382810..5383169 + 360 Protein_5197 IS1 family transposase -
KFU55_RS26400 (5383959) 5383959..5384285 - 327 WP_004201125.1 C2H2-type zinc finger protein -
KFU55_RS26405 (5384467) 5384467..5384748 + 282 WP_001568067.1 hypothetical protein -
KFU55_RS26410 (5384802) 5384802..5385413 + 612 WP_000176305.1 DUF2913 family protein -
KFU55_RS26415 (5385410) 5385410..5385520 - 111 Protein_5201 hypothetical protein -
KFU55_RS26420 (5385562) 5385562..5385669 - 108 Protein_5202 IS6 family transposase -
KFU55_RS26425 (5385823) 5385823..5386245 + 423 WP_004181893.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
KFU55_RS26430 (5386245) 5386245..5387516 + 1272 WP_004181894.1 translesion error-prone DNA polymerase V subunit UmuC -
KFU55_RS26435 (5387617) 5387617..5388060 + 444 WP_004181895.1 DUF2384 domain-containing protein Antitoxin
KFU55_RS26440 (5388057) 5388057..5388527 + 471 WP_004181896.1 RES family NAD+ phosphorylase Toxin
KFU55_RS26445 (5388637) 5388637..5388897 - 261 WP_206552253.1 hypothetical protein -
KFU55_RS26450 (5389596) 5389596..5390965 + 1370 WP_085949440.1 IS3-like element ISKpn8 family transposase -
KFU55_RS26455 (5391142) 5391142..5391852 + 711 Protein_5209 ISNCY family transposase -
KFU55_RS26460 (5392107) 5392107..5393180 - 1074 Protein_5210 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5372993..5392105 19112


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17549.81 Da        Isoelectric Point: 4.6155

>T200246 WP_004181896.1 NZ_CP073782:5388057-5388527 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T200246 NZ_CP097726:3599852-3600070 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16536.87 Da        Isoelectric Point: 10.3013

>AT200246 WP_004181895.1 NZ_CP073782:5387617-5388060 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT200246 NZ_CP097726:3599452-3599826 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LR54

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4RLY9

References