Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | stbDE/ParE-DnaT |
| Location | 4852839..4853361 | Replicon | chromosome |
| Accession | NZ_CP073782 | ||
| Organism | Klebsiella pneumoniae strain IRQBAS106c-genome | ||
Toxin (Protein)
| Gene name | stbE | Uniprot ID | A0A2J4R0S6 |
| Locus tag | KFU55_RS23490 | Protein ID | WP_004181778.1 |
| Coordinates | 4852839..4853123 (-) | Length | 95 a.a. |
Antitoxin (Protein)
| Gene name | stbD | Uniprot ID | A0A5Q9LM53 |
| Locus tag | KFU55_RS23495 | Protein ID | WP_025368601.1 |
| Coordinates | 4853113..4853361 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFU55_RS23470 (4848217) | 4848217..4849343 | + | 1127 | Protein_4616 | conjugal transfer protein TraG N-terminal domain-containing protein | - |
| KFU55_RS23475 (4849409) | 4849409..4850635 | - | 1227 | WP_025368604.1 | RNA-guided endonuclease TnpB family protein | - |
| KFU55_RS23480 (4850672) | 4850672..4851097 | + | 426 | WP_040120489.1 | IS200/IS605 family transposase | - |
| KFU55_RS23485 (4851383) | 4851383..4852609 | - | 1227 | WP_042935575.1 | RNA-guided endonuclease TnpB family protein | - |
| KFU55_RS23490 (4852839) | 4852839..4853123 | - | 285 | WP_004181778.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KFU55_RS23495 (4853113) | 4853113..4853361 | - | 249 | WP_025368601.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KFU55_RS23500 (4853652) | 4853652..4855451 | + | 1800 | WP_085803536.1 | ATP-dependent helicase | - |
| KFU55_RS23505 (4855785) | 4855785..4856780 | + | 996 | WP_046654939.1 | hypothetical protein | - |
| KFU55_RS23510 (4856925) | 4856925..4857278 | + | 354 | WP_004181774.1 | hypothetical protein | - |
| KFU55_RS23515 (4857340) | 4857340..4858161 | + | 822 | WP_046664185.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4805704..4869907 | 64203 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 10970.69 Da Isoelectric Point: 10.6516
>T200243 WP_004181778.1 NZ_CP073782:c4853123-4852839 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN
Download Length: 285 bp
>T200243 NZ_CP097726:2781101-2781208 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 8906.12 Da Isoelectric Point: 3.8206
>AT200243 WP_025368601.1 NZ_CP073782:c4853361-4853113 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL
Download Length: 249 bp
>AT200243 NZ_CP097726:c2781051-2780988 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4R0S6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q9LM53 |