200242

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4580064..4580580 Replicon chromosome
Accession NZ_CP073782
Organism Klebsiella pneumoniae strain IRQBAS106c-genome

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KFU55_RS22245 Protein ID WP_117260273.1
Coordinates 4580296..4580580 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KFU55_RS22240 Protein ID WP_002886901.1
Coordinates 4580064..4580306 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU55_RS22225 (4576092) 4576092..4576832 + 741 WP_002886899.1 KDGP aldolase family protein -
KFU55_RS22230 (4576899) 4576899..4578053 + 1155 WP_002886900.1 lactonase family protein -
KFU55_RS22235 (4578076) 4578076..4579986 + 1911 WP_004152270.1 PRD domain-containing protein -
KFU55_RS22240 (4580064) 4580064..4580306 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KFU55_RS22245 (4580296) 4580296..4580580 + 285 WP_117260273.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KFU55_RS22250 (4580584) 4580584..4581048 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KFU55_RS22255 (4581290) 4581290..4583428 - 2139 WP_040164650.1 anaerobic ribonucleoside-triphosphate reductase -
KFU55_RS22260 (4583785) 4583785..4584528 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KFU55_RS22265 (4584531) 4584531..4584704 - 174 WP_032410138.1 hypothetical protein -
KFU55_RS22270 (4584789) 4584789..4585097 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11127.96 Da        Isoelectric Point: 10.3787

>T200242 WP_117260273.1 NZ_CP073782:4580296-4580580 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQVVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T200242 NZ_CP097726:2780566-2780673 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT200242 WP_002886901.1 NZ_CP073782:4580064-4580306 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT200242 NZ_CP097726:c2780513-2780452 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References