Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1489716..1490354 Replicon chromosome
Accession CP009789
Organism Escherichia coli K-12 strain ER3413

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag ER3413_4551 Protein ID AIZ54218.1
Coordinates 1489716..1489892 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ER3413_1470 Protein ID AIZ51237.1
Coordinates 1489938..1490354 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ER3413_1464 1485335..1486510 - 1176 AIZ51233.1 inner membrane protein, predicted transporter, function unknown -
ER3413_1465 1486602..1487138 + 537 AIZ51234.1 putative DNA-binding transcriptional regulator -
ER3413_1466 1487211..1489172 + 1962 AIZ51235.1 putative peptidase -
ER3413_1467 1489264..1489494 - 231 AIZ51236.1 hypothetical protein -
ER3413_4551 1489716..1489892 + 177 AIZ54218.1 mRNA interferase toxin of the HicAB toxin-antitoxin system Toxin
ER3413_1470 1489938..1490354 + 417 AIZ51237.1 antitoxin for the HicAB toxin-antitoxin system Antitoxin
ER3413_1471 1490433..1491839 + 1407 AIZ51238.1 fused predicted DNA-binding transcriptional regulator/predicted amino transferase -
ER3413_1472 1492084..1493229 + 1146 AIZ51239.1 polyhydroxybutyrate (PHB) synthase, ABC transporter periplasmic binding protein homolog -
ER3413_1473 1493247..1494260 + 1014 AIZ51240.1 putative spermidine/putrescine transporter subunit -
ER3413_1474 1494261..1495202 + 942 AIZ51241.1 putative spermidine/putrescine transporter subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T20024 AIZ54218.1 CP009789:1489716-1489892 [Escherichia coli K-12]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T20024 CP009789:1489716-1489892 [Escherichia coli K-12]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT20024 AIZ51237.1 CP009789:1489938-1490354 [Escherichia coli K-12]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT20024 CP009789:1489938-1490354 [Escherichia coli K-12]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References