Detailed information of TA system TA200238

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3831049..3832730
• Replicon: chromosome
• Accession: NZ_CP073782
• Organism: Klebsiella pneumoniae strain IRQBAS106c-genome

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: KFU55_RS18570
• Protein ID: WP_015959269.1
• Coordinates: 3831855..3832730 (+)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: KFU55_RS18565
• Protein ID: WP_130947194.1
• Coordinates: 3831049..3831807 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFU55_RS18550 (3826899)	3826899..3827585	-	687	WP_004151733.1	tetratricopeptide repeat protein	-
KFU55_RS18555 (3827815)	3827815..3829962	-	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
KFU55_RS18560 (3830235)	3830235..3830963	+	729	WP_004177810.1	response regulator transcription factor	-
KFU55_RS18565 (3831049)	3831049..3831807	+	759	WP_130947194.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
KFU55_RS18570 (3831855)	3831855..3832730	+	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KFU55_RS18575 (3832855)	3832855..3833862	-	1008	WP_015959270.1	carbohydrate kinase family protein	-
KFU55_RS18580 (3833937)	3833937..3834878	-	942	WP_002885156.1	ABC transporter substrate-binding protein	-
KFU55_RS18585 (3834909)	3834909..3835907	-	999	WP_002885172.1	ribose ABC transporter permease	-
KFU55_RS18590 (3835904)	3835904..3837424	-	1521	WP_049005954.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T200238 WP_015959269.1 NZ_CP073782:3831855-3832730 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

>T200238 NZ_CP097726:2149150-2149253 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28532.93 Da
• Isoelectric Point: 10.0870

>AT200238 WP_130947194.1 NZ_CP073782:3831049-3831807 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQAVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT200238 NZ_CP097726:c2149291-2149020 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: A6TH06