Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 1686350..1686969 | Replicon | chromosome |
Accession | NZ_CP073782 | ||
Organism | Klebsiella pneumoniae strain IRQBAS106c-genome |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | KFU55_RS08235 | Protein ID | WP_002892050.1 |
Coordinates | 1686350..1686568 (-) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | J2DPF6 |
Locus tag | KFU55_RS08240 | Protein ID | WP_002892066.1 |
Coordinates | 1686595..1686969 (-) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KFU55_RS08200 (1682397) | 1682397..1682660 | + | 264 | WP_002892011.1 | type B 50S ribosomal protein L31 | - |
KFU55_RS08205 (1682660) | 1682660..1682800 | + | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
KFU55_RS08210 (1682797) | 1682797..1683495 | - | 699 | WP_117260135.1 | GNAT family protein | - |
KFU55_RS08215 (1683596) | 1683596..1685047 | + | 1452 | WP_002892023.1 | PLP-dependent aminotransferase family protein | - |
KFU55_RS08220 (1685022) | 1685022..1685492 | - | 471 | WP_002892026.1 | YlaC family protein | - |
KFU55_RS08225 (1685513) | 1685513..1685653 | + | 141 | WP_004147370.1 | hypothetical protein | - |
KFU55_RS08230 (1685625) | 1685625..1686191 | - | 567 | WP_002892030.1 | maltose O-acetyltransferase | - |
KFU55_RS08235 (1686350) | 1686350..1686568 | - | 219 | WP_002892050.1 | HHA domain-containing protein | Toxin |
KFU55_RS08240 (1686595) | 1686595..1686969 | - | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
KFU55_RS08245 (1687455) | 1687455..1690601 | - | 3147 | WP_002892069.1 | multidrug efflux RND transporter permease subunit AcrB | - |
KFU55_RS08250 (1690624) | 1690624..1691817 | - | 1194 | WP_004177236.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T200227 WP_002892050.1 NZ_CP073782:c1686568-1686350 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T200227 NZ_CP097724:4030526-4030864 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAACCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCACTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTGATTAG
TAACAAAACGCCACGCTAA
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAACCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCACTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTGATTAG
TAACAAAACGCCACGCTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT200227 WP_002892066.1 NZ_CP073782:c1686969-1686595 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT200227 NZ_CP097724:c4030531-4030455 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GJ93 |