Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1686350..1686969 Replicon chromosome
Accession NZ_CP073782
Organism Klebsiella pneumoniae strain IRQBAS106c-genome

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KFU55_RS08235 Protein ID WP_002892050.1
Coordinates 1686350..1686568 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KFU55_RS08240 Protein ID WP_002892066.1
Coordinates 1686595..1686969 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU55_RS08200 (1682397) 1682397..1682660 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
KFU55_RS08205 (1682660) 1682660..1682800 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KFU55_RS08210 (1682797) 1682797..1683495 - 699 WP_117260135.1 GNAT family protein -
KFU55_RS08215 (1683596) 1683596..1685047 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KFU55_RS08220 (1685022) 1685022..1685492 - 471 WP_002892026.1 YlaC family protein -
KFU55_RS08225 (1685513) 1685513..1685653 + 141 WP_004147370.1 hypothetical protein -
KFU55_RS08230 (1685625) 1685625..1686191 - 567 WP_002892030.1 maltose O-acetyltransferase -
KFU55_RS08235 (1686350) 1686350..1686568 - 219 WP_002892050.1 HHA domain-containing protein Toxin
KFU55_RS08240 (1686595) 1686595..1686969 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KFU55_RS08245 (1687455) 1687455..1690601 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KFU55_RS08250 (1690624) 1690624..1691817 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T200227 WP_002892050.1 NZ_CP073782:c1686568-1686350 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T200227 NZ_CP097724:4030526-4030864 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAACCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCACTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTGATTAG
TAACAAAACGCCACGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT200227 WP_002892066.1 NZ_CP073782:c1686969-1686595 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT200227 NZ_CP097724:c4030531-4030455 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References