Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 4793931..4794463 Replicon chromosome
Accession NZ_CP073778
Organism Streptomyces lavendulae subsp. lavendulae strain Del-LP

Toxin (Protein)


Gene name relE Uniprot ID A0A2K8PI76
Locus tag SLLC_RS20785 Protein ID WP_030240465.1
Coordinates 4793931..4794194 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2K8PI77
Locus tag SLLC_RS20790 Protein ID WP_030240463.1
Coordinates 4794191..4794463 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SLLC_RS20760 (SLLC_21255) 4789348..4790310 + 963 WP_030240471.1 permease-like cell division protein FtsX -
SLLC_RS20765 4790391..4791548 - 1158 Protein_4112 transposase -
SLLC_RS20770 (SLLC_21265) 4791682..4792866 + 1185 WP_030240468.1 S41 family peptidase -
SLLC_RS20775 (SLLC_21270) 4792885..4793370 + 486 WP_030240466.1 SsrA-binding protein SmpB -
SLLC_RS20785 (SLLC_21280) 4793931..4794194 - 264 WP_030240465.1 Txe/YoeB family addiction module toxin Toxin
SLLC_RS20790 (SLLC_21285) 4794191..4794463 - 273 WP_030240463.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
SLLC_RS20795 (SLLC_21290) 4794606..4795829 - 1224 WP_051841488.1 SH3 domain-containing protein -
SLLC_RS20800 (SLLC_21295) 4795875..4797158 - 1284 WP_208754752.1 MFS transporter -
SLLC_RS20805 (SLLC_21300) 4797277..4798245 + 969 WP_030239199.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-71)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10278.65 Da        Isoelectric Point: 8.4857

>T200225 WP_030240465.1 NZ_CP073778:c4794194-4793931 [Streptomyces lavendulae subsp. lavendulae]
VRSVHFDPDAWEDFLFWLGADRKMARRITRLIGEIQSSPFAGIGKPEPLKGDLTGYWSRRIDDEHRLVYRADDKEVKILK
ARYHYSD

Download         Length: 264 bp

>T200225 NZ_CP097724:c3877868-3877554 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9962.24 Da        Isoelectric Point: 4.6286

>AT200225 WP_030240463.1 NZ_CP073778:c4794463-4794191 [Streptomyces lavendulae subsp. lavendulae]
MPISASEARKTLFPLIERVNDDHVPVRISSKNGDAVLMSAADYDSWQETVYLLRSPANARRLMEAVARDREGIASVTKSM
EELQALAGDE

Download         Length: 273 bp

>AT200225 NZ_CP097724:c3878104-3877871 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8PI76

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8PI77

References