Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3416544..3417187 Replicon chromosome
Accession NZ_CP073778
Organism Streptomyces lavendulae subsp. lavendulae strain Del-LP

Toxin (Protein)


Gene name vapC Uniprot ID A0A2K8PEP1
Locus tag SLLC_RS14310 Protein ID WP_030236472.1
Coordinates 3416544..3416960 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2K8PGB5
Locus tag SLLC_RS14315 Protein ID WP_030236475.1
Coordinates 3416957..3417187 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SLLC_RS14295 (SLLC_14695) 3412157..3412999 - 843 WP_234333794.1 trypsin-like serine protease -
SLLC_RS14300 (SLLC_14700) 3413545..3414783 - 1239 WP_030236466.1 glycosyltransferase -
SLLC_RS14305 (SLLC_14705) 3415445..3416527 + 1083 WP_030236469.1 alpha/beta hydrolase -
SLLC_RS14310 (SLLC_14710) 3416544..3416960 - 417 WP_030236472.1 PIN domain nuclease Toxin
SLLC_RS14315 (SLLC_14715) 3416957..3417187 - 231 WP_030236475.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
SLLC_RS14320 (SLLC_14720) 3417294..3418514 - 1221 WP_030236479.1 amidohydrolase family protein -
SLLC_RS14325 (SLLC_14725) 3418670..3421747 + 3078 WP_030236481.1 BTAD domain-containing putative transcriptional regulator -
SLLC_RS14330 (SLLC_14730) 3421944..3422144 + 201 WP_030236484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(17-122)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14990.12 Da        Isoelectric Point: 6.0794

>T200224 WP_030236472.1 NZ_CP073778:c3416960-3416544 [Streptomyces lavendulae subsp. lavendulae]
MTRHFLIDKSALARYPKPAVRAVVNPLHTAGVLAVCGAVELEVLYSARSKSDADRVRAGLGAFAWLSTPDEAWDRALEVQ
EQLIVAGNWKAVSLPDLIIAATAERHEATVLHYDGDYDMIAKVTGQPTRWVVPPGTAD

Download         Length: 417 bp

>T200224 NZ_CP097724:3438556-3438774 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8129.20 Da        Isoelectric Point: 4.5535

>AT200224 WP_030236475.1 NZ_CP073778:c3417187-3416957 [Streptomyces lavendulae subsp. lavendulae]
MARTVIDVDDALLAEAAELFGTKTKVATVNAALRDAVNRRKREEFLNWLAEGGLPDLTGPVELLAAEGGHVQDRAA

Download         Length: 231 bp

>AT200224 NZ_CP097724:3438156-3438530 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8PEP1

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8PGB5

References