Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 2922472..2922997 Replicon chromosome
Accession NZ_CP073778
Organism Streptomyces lavendulae subsp. lavendulae strain Del-LP

Toxin (Protein)


Gene name relE Uniprot ID A0A2K8PD81
Locus tag SLLC_RS11890 Protein ID WP_030226168.1
Coordinates 2922734..2922997 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S5UWF1
Locus tag SLLC_RS11885 Protein ID WP_019434848.1
Coordinates 2922472..2922741 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SLLC_RS11860 (SLLC_12245) 2918048..2919199 - 1152 WP_030226154.1 alpha/beta hydrolase-fold protein -
SLLC_RS11865 (SLLC_12250) 2919360..2919797 - 438 WP_199922123.1 MarR family transcriptional regulator -
SLLC_RS11870 (SLLC_12255) 2919875..2920888 + 1014 WP_030226158.1 SMP-30/gluconolactonase/LRE family protein -
SLLC_RS11875 (SLLC_12260) 2921022..2921636 + 615 WP_051840334.1 DUF308 domain-containing protein -
SLLC_RS11880 (SLLC_12265) 2921773..2922018 + 246 WP_030226163.1 hypothetical protein -
SLLC_RS11885 (SLLC_12270) 2922472..2922741 + 270 WP_019434848.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SLLC_RS11890 (SLLC_12275) 2922734..2922997 + 264 WP_030226168.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SLLC_RS11895 (SLLC_12280) 2923105..2924274 + 1170 WP_030226170.1 hypothetical protein -
SLLC_RS11900 (SLLC_12285) 2924781..2926457 + 1677 WP_030226173.1 Eco57I restriction-modification methylase domain-containing protein -
SLLC_RS11905 (SLLC_12290) 2926471..2927220 + 750 WP_030226176.1 PaeR7I family type II restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-58)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10084.54 Da        Isoelectric Point: 8.5042

>T200223 WP_030226168.1 NZ_CP073778:2922734-2922997 [Streptomyces lavendulae subsp. lavendulae]
VSEYRTVFRPEAQAELRKIPRDMALRILAKLTELESDPLGFNTTALVSQPERRRLRVGDYRVLYTIDNGELVVWVVHVGH
RSTVYDT

Download         Length: 264 bp

>T200223 NZ_CP097724:2678842-2678949 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10259.71 Da        Isoelectric Point: 4.6265

>AT200223 WP_019434848.1 NZ_CP073778:2922472-2922741 [Streptomyces lavendulae subsp. lavendulae]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARGE

Download         Length: 270 bp

>AT200223 NZ_CP097724:c2678789-2678728 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8PD81

Antitoxin

Source ID Structure
AlphaFold DB S5UWF1

References