Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3837634..3838291 Replicon chromosome
Accession NZ_CP073771
Organism Enterobacter hormaechei strain SH19PTE2

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag KFO54_RS18630 Protein ID WP_022649305.1
Coordinates 3837634..3838044 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag KFO54_RS18635 Protein ID WP_003863437.1
Coordinates 3838025..3838291 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFO54_RS18610 (KFO54_18610) 3833632..3835365 - 1734 WP_211989388.1 single-stranded-DNA-specific exonuclease RecJ -
KFO54_RS18615 (KFO54_18615) 3835371..3836084 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KFO54_RS18620 (KFO54_18620) 3836113..3837009 - 897 WP_211989390.1 site-specific tyrosine recombinase XerD -
KFO54_RS18625 (KFO54_18625) 3837111..3837632 + 522 WP_003863440.1 flavodoxin FldB -
KFO54_RS18630 (KFO54_18630) 3837634..3838044 - 411 WP_022649305.1 protein YgfX Toxin
KFO54_RS18635 (KFO54_18635) 3838025..3838291 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
KFO54_RS18640 (KFO54_18640) 3838586..3839566 + 981 WP_003863435.1 tRNA-modifying protein YgfZ -
KFO54_RS18645 (KFO54_18645) 3839652..3840311 - 660 WP_003863433.1 hemolysin III family protein -
KFO54_RS18650 (KFO54_18650) 3840578..3841309 + 732 WP_003863431.1 MurR/RpiR family transcriptional regulator -
KFO54_RS18655 (KFO54_18655) 3841426..3842859 + 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T200218 WP_022649305.1 NZ_CP073771:c3838044-3837634 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T200218 NZ_CP097724:1900401-1900652 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAGGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCTGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT200218 WP_003863437.1 NZ_CP073771:c3838291-3838025 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT200218 NZ_CP097724:1900649-1900903 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCAGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References