Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2295215..2295954 Replicon chromosome
Accession NZ_CP073771
Organism Enterobacter hormaechei strain SH19PTE2

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag KFO54_RS11130 Protein ID WP_211988991.1
Coordinates 2295215..2295700 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag KFO54_RS11135 Protein ID WP_211988999.1
Coordinates 2295688..2295954 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFO54_RS11110 (KFO54_11110) 2291369..2292127 - 759 WP_023314159.1 trans-aconitate 2-methyltransferase -
KFO54_RS11115 (KFO54_11115) 2292212..2292796 - 585 WP_211988987.1 GDP-mannose pyrophosphatase -
KFO54_RS11120 (KFO54_11120) 2292883..2293641 + 759 WP_003857136.1 DeoR/GlpR family DNA-binding transcription regulator -
KFO54_RS11125 (KFO54_11125) 2293746..2295038 + 1293 WP_211988989.1 glycosyl hydrolase family 28 protein -
KFO54_RS11130 (KFO54_11130) 2295215..2295700 - 486 WP_211988991.1 GNAT family N-acetyltransferase Toxin
KFO54_RS11135 (KFO54_11135) 2295688..2295954 - 267 WP_211988999.1 DUF1778 domain-containing protein Antitoxin
KFO54_RS11140 (KFO54_11140) 2296018..2296947 - 930 WP_211989000.1 LysR family transcriptional regulator -
KFO54_RS11145 (KFO54_11145) 2297077..2298465 + 1389 WP_023314162.1 MFS transporter -
KFO54_RS11150 (KFO54_11150) 2298487..2299482 - 996 WP_126296800.1 DUF2891 domain-containing protein -
KFO54_RS11155 (KFO54_11155) 2299492..2300478 - 987 WP_211989001.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17506.22 Da        Isoelectric Point: 9.9658

>T200208 WP_211988991.1 NZ_CP073771:c2295700-2295215 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGLYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T200208 NZ_CP097721:c4519919-4519608 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9998.44 Da        Isoelectric Point: 4.4857

>AT200208 WP_211988999.1 NZ_CP073771:c2295954-2295688 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWGV

Download         Length: 267 bp

>AT200208 NZ_CP097721:c4519607-4519317 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References