Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1087680..1088300 Replicon chromosome
Accession NZ_CP073771
Organism Enterobacter hormaechei strain SH19PTE2

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag KFO54_RS05160 Protein ID WP_015571250.1
Coordinates 1087680..1087898 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag KFO54_RS05165 Protein ID WP_006809850.1
Coordinates 1087926..1088300 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFO54_RS05130 (KFO54_05135) 1083692..1083952 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
KFO54_RS05135 (KFO54_05140) 1083955..1084095 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
KFO54_RS05140 (KFO54_05145) 1084092..1084802 - 711 WP_022650493.1 GNAT family protein -
KFO54_RS05145 (KFO54_05150) 1084904..1086364 + 1461 WP_211989177.1 PLP-dependent aminotransferase family protein -
KFO54_RS05150 (KFO54_05155) 1086336..1086803 - 468 WP_022650495.1 YlaC family protein -
KFO54_RS05155 (KFO54_05160) 1086920..1087471 - 552 WP_022650496.1 maltose O-acetyltransferase -
KFO54_RS05160 (KFO54_05165) 1087680..1087898 - 219 WP_015571250.1 HHA domain-containing protein Toxin
KFO54_RS05165 (KFO54_05170) 1087926..1088300 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
KFO54_RS05170 (KFO54_05175) 1088811..1091957 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit AcrB -
KFO54_RS05175 (KFO54_05180) 1091980..1093173 - 1194 WP_022650498.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T200206 WP_015571250.1 NZ_CP073771:c1087898-1087680 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T200206 NZ_CP097721:c4132583-4132233 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT200206 WP_006809850.1 NZ_CP073771:c1088300-1087926 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT200206 NZ_CP097721:c4132828-4132577 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References