Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 579538..580309 Replicon chromosome
Accession NZ_CP073771
Organism Enterobacter hormaechei strain SH19PTE2

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KFO54_RS02765 Protein ID WP_064355271.1
Coordinates 579935..580309 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KFO54_RS02760 Protein ID WP_047720742.1
Coordinates 579538..579897 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFO54_RS02715 (KFO54_02715) 575163..575840 + 678 WP_211988806.1 WYL domain-containing protein -
KFO54_RS02720 (KFO54_02720) 575948..576358 + 411 WP_064355305.1 hypothetical protein -
KFO54_RS02725 (KFO54_02725) 576413..576772 + 360 WP_010434179.1 hypothetical protein -
KFO54_RS02730 (KFO54_02730) 576853..577065 + 213 WP_010434180.1 hypothetical protein -
KFO54_RS02735 (KFO54_02735) 577177..577998 + 822 WP_064355269.1 DUF932 domain-containing protein -
KFO54_RS02740 (KFO54_02740) 578078..578557 + 480 WP_077267042.1 antirestriction protein -
KFO54_RS25430 578568..578708 + 141 WP_226863590.1 hypothetical protein -
KFO54_RS02750 (KFO54_02750) 578798..579280 + 483 WP_064355270.1 DNA repair protein RadC -
KFO54_RS02755 (KFO54_02755) 579294..579515 + 222 WP_032938028.1 DUF987 domain-containing protein -
KFO54_RS02760 (KFO54_02760) 579538..579897 + 360 WP_047720742.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KFO54_RS02765 (KFO54_02765) 579935..580309 + 375 WP_064355271.1 TA system toxin CbtA family protein Toxin
KFO54_RS02770 (KFO54_02770) 580848..581837 - 990 WP_211988808.1 glycosyltransferase -
KFO54_RS02775 (KFO54_02775) 582442..583236 + 795 WP_077267041.1 helix-turn-helix transcriptional regulator -
KFO54_RS02780 (KFO54_02780) 583704..585131 + 1428 WP_064355274.1 phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island fosA - 544235..592581 48346


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(9-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13932.91 Da        Isoelectric Point: 8.8971

>T200205 WP_064355271.1 NZ_CP073771:579935-580309 [Enterobacter hormaechei]
MQIQSLPPQRAASSRLSSVEIWQKLLEYLLEQHYGLTLNDTPFGNDSVIQKHIDAGISLCDAVNFIVEKYDLVRTDRHGF
SVKEQSPFIGSIDMLRARKATGLMTRKGYKTVTDITGGRFSEGK

Download         Length: 375 bp

>T200205 NZ_CP097721:c4044880-4044503 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13394.53 Da        Isoelectric Point: 8.1441

>AT200205 WP_047720742.1 NZ_CP073771:579538-579897 [Enterobacter hormaechei]
MQKATRVINHNIAEPWWGLRRNVTPCFGARLVQEGNRLHYLADRASTTGTFNDADLRHLDQAFPLLMKQMELMLTSSELM
PRIQRCITLHAKGLICEADTLGSCGYLYIVIYPASATTA

Download         Length: 360 bp

>AT200205 NZ_CP097721:c4045301-4044927 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCAGATGCATACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAATCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References