Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RelE-RHH |
Location | 36994..37541 | Replicon | plasmid pYUSHP6-3 |
Accession | NZ_CP073770 | ||
Organism | Escherichia coli strain SH19PTE6 |
Toxin (Protein)
Gene name | parE | Uniprot ID | - |
Locus tag | KEH54_RS23305 | Protein ID | WP_244461891.1 |
Coordinates | 37308..37541 (+) | Length | 78 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | A0A829FT18 |
Locus tag | KEH54_RS23300 | Protein ID | WP_000079938.1 |
Coordinates | 36994..37263 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KEH54_RS23280 (KEH54_23285) | 32548..33705 | + | 1158 | WP_000217345.1 | alpha-hydroxy acid oxidase | - |
KEH54_RS23285 (KEH54_23290) | 33739..34824 | + | 1086 | WP_001148851.1 | iron-containing alcohol dehydrogenase family protein | - |
KEH54_RS23290 (KEH54_23295) | 34914..35225 | - | 312 | WP_024191312.1 | hypothetical protein | - |
KEH54_RS23295 (KEH54_23300) | 35279..36259 | + | 981 | WP_071940815.1 | IS5-like element ISKpn26 family transposase | - |
KEH54_RS23300 (KEH54_23305) | 36994..37263 | + | 270 | WP_000079938.1 | type II toxin-antitoxin system antitoxin YacA | Antitoxin |
KEH54_RS23305 (KEH54_23310) | 37308..37541 | + | 234 | WP_244461891.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
KEH54_RS23310 (KEH54_23315) | 37599..37730 | + | 132 | Protein_41 | IS3 family transposase | - |
KEH54_RS23320 (KEH54_23325) | 38562..38966 | + | 405 | WP_240725492.1 | hypothetical protein | - |
KEH54_RS23325 (KEH54_23330) | 39257..40780 | + | 1524 | WP_000921251.1 | hypothetical protein | - |
KEH54_RS23330 (KEH54_23335) | 40815..41939 | + | 1125 | WP_032174239.1 | DUF4238 domain-containing protein | - |
KEH54_RS23335 (KEH54_23340) | 41939..42229 | + | 291 | WP_000648897.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | - | - | 1..64665 | 64665 | |
- | inside | IScluster/Tn | - | - | 20487..49099 | 28612 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 78 a.a. Molecular weight: 8940.20 Da Isoelectric Point: 6.7231
>T200201 WP_244461891.1 NZ_CP073770:37308-37541 [Escherichia coli]
IREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGARELVIHPHFVLVYEVDSQWEKVYILRVLHTTQKWP
IREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGARELVIHPHFVLVYEVDSQWEKVYILRVLHTTQKWP
Download Length: 234 bp
>T200201 NZ_CP097721:3414787-3415005 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10251.64 Da Isoelectric Point: 10.1734
>AT200201 WP_000079938.1 NZ_CP073770:36994-37263 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLKRGDVLPHDMVESSAAAWRD
EMSRKVADK
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLKRGDVLPHDMVESSAAAWRD
EMSRKVADK
Download Length: 270 bp
>AT200201 NZ_CP097721:3414387-3414761 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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