Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1892925..1893756 Replicon chromosome
Accession NZ_CP073768
Organism Escherichia coli strain SH19PTE6

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag KEH54_RS09100 Protein ID WP_000854814.1
Coordinates 1892925..1893299 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag KEH54_RS09105 Protein ID WP_001285585.1
Coordinates 1893388..1893756 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEH54_RS09060 (1888321) 1888321..1889487 + 1167 WP_016247321.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
KEH54_RS09065 (1889606) 1889606..1890079 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
KEH54_RS09070 (1890277) 1890277..1891335 + 1059 WP_064670363.1 FUSC family protein -
KEH54_RS09075 (1891507) 1891507..1891836 + 330 WP_000450409.1 DUF496 family protein -
KEH54_RS09080 (1891937) 1891937..1892071 - 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
KEH54_RS09085 (1892191) 1892191..1892319 + 129 Protein_1805 transposase domain-containing protein -
KEH54_RS09090 (1892608) 1892608..1892688 - 81 Protein_1806 hypothetical protein -
KEH54_RS09095 (1892734) 1892734..1892928 - 195 WP_000988600.1 DUF5983 family protein -
KEH54_RS09100 (1892925) 1892925..1893299 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
KEH54_RS09105 (1893388) 1893388..1893756 - 369 WP_001285585.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
KEH54_RS09110 (1893830) 1893830..1894051 - 222 WP_000692323.1 DUF987 domain-containing protein -
KEH54_RS09115 (1894114) 1894114..1894590 - 477 WP_001186773.1 RadC family protein -
KEH54_RS09120 (1894606) 1894606..1895085 - 480 WP_000860076.1 antirestriction protein -
KEH54_RS09125 (1895167) 1895167..1895988 - 822 WP_064670364.1 DUF932 domain-containing protein -
KEH54_RS09130 (1896209) 1896209..1896619 - 411 WP_000846713.1 hypothetical protein -
KEH54_RS09135 (1896635) 1896635..1897318 - 684 WP_000775500.1 hypothetical protein -
KEH54_RS09140 (1897454) 1897454..1898524 - 1071 WP_000102643.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1844825..1905112 60287


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T200183 WP_000854814.1 NZ_CP073768:c1893299-1892925 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T200183 NZ_CP097720:c46740-46324 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT200183 WP_001285585.1 NZ_CP073768:c1893756-1893388 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT200183 NZ_CP097720:c46967-46737 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References