Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 10948659..10949137 Replicon chromosome
Accession NZ_CP073767
Organism Dactylosporangium aurantiacum strain NRRL B-8018

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag Daura_RS49010 Protein ID WP_033367965.1
Coordinates 10948659..10948913 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag Daura_RS49015 Protein ID WP_245635824.1
Coordinates 10948910..10949137 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Daura_RS48995 (Daura_48725) 10944141..10945397 + 1257 WP_156090098.1 helix-turn-helix transcriptional regulator -
Daura_RS49000 (Daura_48735) 10946120..10947016 - 897 WP_156090099.1 hypothetical protein -
Daura_RS49005 (Daura_48740) 10947007..10947930 - 924 WP_156090100.1 hypothetical protein -
Daura_RS49010 (Daura_48745) 10948659..10948913 - 255 WP_033367965.1 Txe/YoeB family addiction module toxin Toxin
Daura_RS49015 (Daura_48750) 10948910..10949137 - 228 WP_245635824.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Daura_RS49020 (Daura_48755) 10949643..10949885 + 243 WP_033367192.1 cold shock domain-containing protein -
Daura_RS49025 (Daura_48760) 10949910..10950620 - 711 WP_033367164.1 class I SAM-dependent methyltransferase -
Daura_RS49030 (Daura_48765) 10950626..10951303 - 678 WP_033367165.1 DUF899 family protein -
Daura_RS49035 (Daura_48770) 10951313..10952653 - 1341 WP_052388482.1 FAD-binding oxidoreductase -
Daura_RS49040 (Daura_48775) 10952718..10953593 + 876 WP_033367166.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 10935351..10949610 14259


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-59)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10218.41 Da        Isoelectric Point: 8.9594

>T200175 WP_033367965.1 NZ_CP073767:c10948913-10948659 [Dactylosporangium aurantiacum]
VKVQFASRGWDDYLSWQQDRQMLRRVNALIEDIRRNGHEGIGKPEQLRGNWSGFWSRRIDQEHRLVYRIADDTVQIAQCR
YHYE

Download         Length: 255 bp

>T200175 NZ_CP097719:3315122-3315508 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8121.95 Da        Isoelectric Point: 4.1048

>AT200175 WP_245635824.1 NZ_CP073767:c10949137-10948910 [Dactylosporangium aurantiacum]
MLDHVVDDAEEVVITRSGHESAVIISLREYESLKETAYLMASPANARRLNEAIEELRAGGGEVHDLLDADEASAA

Download         Length: 228 bp

>AT200175 NZ_CP097719:3315498-3315827 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References