Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1888292..1888856 Replicon chromosome
Accession NZ_CP073767
Organism Dactylosporangium aurantiacum strain NRRL B-8018

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag Daura_RS08470 Protein ID WP_033357937.1
Coordinates 1888509..1888856 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag Daura_RS08465 Protein ID WP_033357936.1
Coordinates 1888292..1888522 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Daura_RS08450 (Daura_08430) 1884789..1885946 - 1158 WP_052386328.1 acyltransferase -
Daura_RS08455 (Daura_08435) 1885995..1887845 + 1851 WP_033357934.1 hypothetical protein -
Daura_RS08460 (Daura_08440) 1887864..1888055 - 192 WP_033357935.1 hypothetical protein -
Daura_RS08465 (Daura_08445) 1888292..1888522 + 231 WP_033357936.1 ribbon-helix-helix domain-containing protein Antitoxin
Daura_RS08470 (Daura_08450) 1888509..1888856 + 348 WP_033357937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
Daura_RS08475 (Daura_08455) 1888973..1889302 + 330 WP_033357938.1 hypothetical protein -
Daura_RS08480 (Daura_08460) 1889432..1891036 + 1605 WP_052386329.1 glycosyltransferase 87 family protein -
Daura_RS08485 (Daura_08465) 1891020..1891523 - 504 WP_033357939.1 SRPBCC domain-containing protein -
Daura_RS08490 (Daura_08470) 1891627..1892088 + 462 WP_033357940.1 heme-degrading domain-containing protein -
Daura_RS08495 (Daura_08475) 1892132..1892590 + 459 WP_033357941.1 hypothetical protein -
Daura_RS08500 (Daura_08480) 1892636..1892977 + 342 WP_033357942.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12449.17 Da        Isoelectric Point: 11.2636

>T200173 WP_033357937.1 NZ_CP073767:1888509-1888856 [Dactylosporangium aurantiacum]
MRRGDVFMVELDPAVGSEAAKFRPAVLVSNNAANRVAERNRRGVVTVVPVTSNTARIHPFQTFISAGDGGLAVDSKAQAE
QVRSVDVRRLGRQLGSLKDDTVRSLDEALRLHLAV

Download         Length: 348 bp

>T200173 NZ_CP097719:2909068-2909175 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8574.34 Da        Isoelectric Point: 4.2091

>AT200173 WP_033357936.1 NZ_CP073767:1888292-1888522 [Dactylosporangium aurantiacum]
MKVSVSLPSDDISFVDDYARRRGNASRSSVLHQAIELLRLSEMEQSYSDAWDEWADGDDAKLWERTAADGITDAPR

Download         Length: 231 bp

>AT200173 NZ_CP097719:c2909015-2908954 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References