Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 358895..359703 Replicon chromosome
Accession NZ_CP073767
Organism Dactylosporangium aurantiacum strain NRRL B-8018

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag Daura_RS01650 Protein ID WP_245635611.1
Coordinates 358895..359395 (-) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag Daura_RS01655 Protein ID WP_033363161.1
Coordinates 359413..359703 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Daura_RS01630 (Daura_01615) 354414..357173 + 2760 WP_033363164.1 Hsp70 family protein -
Daura_RS01635 (Daura_01620) 357229..358320 - 1092 WP_033363163.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -
Daura_RS01645 (Daura_01630) 358598..358768 - 171 WP_156089984.1 hypothetical protein -
Daura_RS01650 (Daura_01635) 358895..359395 - 501 WP_245635611.1 GNAT family N-acetyltransferase Toxin
Daura_RS01655 (Daura_01640) 359413..359703 - 291 WP_033363161.1 DUF1778 domain-containing protein Antitoxin
Daura_RS01660 (Daura_01645) 359700..360236 - 537 WP_162189871.1 hypothetical protein -
Daura_RS01665 (Daura_01650) 360120..360522 + 403 Protein_327 CBS domain-containing protein -
Daura_RS01670 (Daura_01655) 360562..361998 - 1437 WP_260709956.1 protein kinase -
Daura_RS01675 (Daura_01660) 362444..363301 + 858 WP_052387723.1 metallophosphoesterase -
Daura_RS01680 (Daura_01665) 363361..364266 + 906 WP_211273756.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(7-81)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 17873.52 Da        Isoelectric Point: 8.5147

>T200172 WP_245635611.1 NZ_CP073767:c359395-358895 [Dactylosporangium aurantiacum]
VEPLSAGHSVAGFDCGSQAQSVWLIEHALQAHRAGLSRVYVVRDNDHTDRRVVGYYALAAGSVAPAEASPRLRQGAGRYH
QPVVILTRLGVDLAAQGAGLGRALVVDALRRVASAAEVIGMRAVLIHCETEAARDFYLRLAKFEASPTDPMHLLLLMKDL
RRALDG

Download         Length: 501 bp

>T200172 NZ_CP097719:c2653880-2653704 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTGGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCAAGGGCGACGCAGTGTCATGCCACGTCACCCCAGTGATGAGATAAAAGAACCATTGCGTAAAGCAATCCTGAAGC
AACTCGGTTTAAATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10163.50 Da        Isoelectric Point: 4.5437

>AT200172 WP_033363161.1 NZ_CP073767:c359703-359413 [Dactylosporangium aurantiacum]
VSAKGDRLHLRLDAEQKAMLEAASRAAGDTVSTFVLKAATEAAADVLADRRVFVLAQDAWQVFDDALQRPPQDIAGLKEL
LAGPTVLDPPQGGTPQ

Download         Length: 291 bp

>AT200172 NZ_CP097719:c2653660-2653244 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACTCCTGCGCCGGAAGGCGGTTATGTGGTTTCTTTTGTAGATATCCCTGAAGCGTTGAC
GCAGGGAGAAACTGTTGCTGAAGCGATGGAAGCAGCAAAAGATGCCTTACTCACCGCATTTGATTTTTATTTTGAAGATA
ATGAGCTAATCCCGTTGCCTTCGCCATTAACTAACAACGATCACTTTATTGAAGTGCCTTTAAGTATCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCTTATTTAACTTGCACCATGCTACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References