Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 62442..63015 Replicon plasmid pHY1
Accession NZ_CP073765
Organism Methylovirgula sp. HY1

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag MHY1_RS16475 Protein ID WP_219324159.1
Coordinates 62442..62780 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag MHY1_RS16480 Protein ID WP_219324161.1
Coordinates 62770..63015 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MHY1_RS16460 (MHY1_p00058) 57957..59735 - 1779 WP_255565212.1 ATP-binding cassette domain-containing protein -
MHY1_RS16465 (MHY1_p00059) 59767..60936 - 1170 WP_219324154.1 efflux RND transporter periplasmic adaptor subunit -
MHY1_RS16470 (MHY1_p00060) 61242..62393 - 1152 WP_219324156.1 RNA-guided endonuclease TnpB family protein -
MHY1_RS16475 (MHY1_p00061) 62442..62780 - 339 WP_219324159.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MHY1_RS16480 (MHY1_p00062) 62770..63015 - 246 WP_219324161.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
MHY1_RS16485 (MHY1_p00063) 63124..63987 - 864 WP_219324163.1 FoF1 ATP synthase subunit gamma -
MHY1_RS16490 (MHY1_p00064) 63987..65537 - 1551 WP_255565213.1 F0F1 ATP synthase subunit alpha -
MHY1_RS16495 (MHY1_p00065) 65515..66273 - 759 WP_219324167.1 F0F1 ATP synthase subunit delta -
MHY1_RS16500 (MHY1_p00066) 66278..66535 - 258 WP_219324169.1 F0F1 ATP synthase subunit C -
MHY1_RS16505 (MHY1_p00067) 66544..67248 - 705 WP_219324171.1 F0F1 ATP synthase subunit A -
MHY1_RS16510 (MHY1_p00068) 67245..67544 - 300 WP_219324173.1 ATP synthase subunit I -
MHY1_RS16515 (MHY1_p00069) 67541..67846 - 306 WP_219324175.1 AtpZ/AtpI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - gmd / ureG 1..278037 278037


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12907.71 Da        Isoelectric Point: 9.0500

>T200170 WP_219324159.1 NZ_CP073765:c62780-62442 [Methylovirgula sp. HY1]
MRYRLRPRAKHNLEAIWDYSAATWGIDRAESYIRQIQTTCELLAGDAHLGRACEEIRPGYRKIRSGSHILFYREAEGDIE
IVRILHQEHVRGGNPGIHAGEEPRSLAKLKFI

Download         Length: 339 bp

>T200170 NZ_CP097719:2214984-2215086 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8695.73 Da        Isoelectric Point: 5.0210

>AT200170 WP_219324161.1 NZ_CP073765:c63015-62770 [Methylovirgula sp. HY1]
MARNTSFTLGDHFAAFVESQVTEGRYASASDVVRAGLRLLEEQEVKLAALRAALIEGETSGPAAPFDFDGFIAHKRGQNA
L

Download         Length: 246 bp

>AT200170 NZ_CP097719:c2215124-2214856 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References