Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 3121843..3122489 Replicon chromosome
Accession NZ_CP073764
Organism Methylovirgula sp. HY1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MHY1_RS14750 Protein ID WP_219320473.1
Coordinates 3121843..3122253 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MHY1_RS14755 Protein ID WP_219320474.1
Coordinates 3122256..3122489 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MHY1_RS14725 (MHY1_03020) 3117633..3118607 + 975 WP_219320468.1 signal peptide peptidase SppA -
MHY1_RS14730 (MHY1_03021) 3118779..3119069 + 291 WP_219320469.1 integration host factor subunit beta -
MHY1_RS14735 (MHY1_03022) 3119109..3119405 + 297 WP_219320470.1 LapA family protein -
MHY1_RS14740 (MHY1_03023) 3119651..3120313 + 663 WP_219320471.1 phosphoribosylanthranilate isomerase -
MHY1_RS14745 (MHY1_03024) 3120393..3121676 + 1284 WP_219320472.1 tryptophan synthase subunit beta -
MHY1_RS14750 (MHY1_03025) 3121843..3122253 - 411 WP_219320473.1 PIN domain-containing protein Toxin
MHY1_RS14755 (MHY1_03026) 3122256..3122489 - 234 WP_219320474.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MHY1_RS14760 (MHY1_03027) 3122611..3123450 + 840 WP_219320475.1 tryptophan synthase subunit alpha -
MHY1_RS14765 (MHY1_03028) 3123640..3124509 + 870 WP_219320476.1 acetyl-CoA carboxylase, carboxyltransferase subunit beta -
MHY1_RS14770 (MHY1_03029) 3124506..3125849 + 1344 WP_219320477.1 folylpolyglutamate synthase/dihydrofolate synthase family protein -
MHY1_RS14775 (MHY1_03030) 3126115..3127167 + 1053 WP_219320478.1 FtsH protease activity modulator HflK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-121)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15059.29 Da        Isoelectric Point: 5.1293

>T200169 WP_219320473.1 NZ_CP073764:c3122253-3121843 [Methylovirgula sp. HY1]
MSDAQRCFFDTNIFVYLAAADVAKADRAEAILAQGGVVSVQVLNEFTSVVSRKQNLSLPEIRDFLATIRTLCEVVPLSVQ
THERGLDLVERFKFSIYDAMIVAAAQLANCTVLYTEDLHHGQVVDGLAIRNPFRVT

Download         Length: 411 bp

>T200169 NZ_CP097719:c2016710-2016336 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8845.15 Da        Isoelectric Point: 8.6793

>AT200169 WP_219320474.1 NZ_CP073764:c3122489-3122256 [Methylovirgula sp. HY1]
MQVAKWGNSLAVRLPKSVVEALQLKEGDEITIELVGAHSFEVEKTPTADDLIARLRKYRGRLPADFRFDRLEAHERR

Download         Length: 234 bp

>AT200169 NZ_CP097719:c2017167-2016799 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References