Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3113151..3113842 Replicon chromosome
Accession NZ_CP073764
Organism Methylovirgula sp. HY1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MHY1_RS14710 Protein ID WP_219320465.1
Coordinates 3113423..3113842 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MHY1_RS14705 Protein ID WP_219320464.1
Coordinates 3113151..3113426 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MHY1_RS14680 (MHY1_03010) 3109230..3109889 + 660 WP_219320459.1 (d)CMP kinase -
MHY1_RS14685 (MHY1_03011) 3109862..3110578 - 717 WP_219320460.1 anti-sigma factor -
MHY1_RS14690 (MHY1_03012) 3110571..3111128 - 558 WP_219320461.1 sigma-70 family RNA polymerase sigma factor -
MHY1_RS14695 (MHY1_03013) 3111348..3111926 + 579 WP_219320462.1 fasciclin domain-containing protein -
MHY1_RS14700 (MHY1_03015) 3112054..3113019 - 966 WP_219320463.1 threonine dehydratase -
MHY1_RS14705 (MHY1_03016) 3113151..3113426 + 276 WP_219320464.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MHY1_RS14710 (MHY1_03017) 3113423..3113842 + 420 WP_219320465.1 type II toxin-antitoxin system VapC family toxin Toxin
MHY1_RS14715 (MHY1_03018) 3114242..3115999 + 1758 WP_219320466.1 30S ribosomal protein S1 -
MHY1_RS14720 (MHY1_03019) 3116085..3117383 + 1299 WP_219320467.1 Hsp70 family protein -
MHY1_RS14725 (MHY1_03020) 3117633..3118607 + 975 WP_219320468.1 signal peptide peptidase SppA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

SpoVT-AbrB domain

(10-47)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14818.14 Da        Isoelectric Point: 8.0220

>T200168 WP_219320465.1 NZ_CP073764:3113423-3113842 [Methylovirgula sp. HY1]
MICLDTNAVIAVINGRTPAVRVHLEAALSAGQQVAVPVIVLFELWFGIVKSLRVAANKRALSVFFANGVEILPFDADDAR
EAGDIRGVLARAGSPIGAYDILIAAQARRRDALLVTANGREFVRVPGLRTEDWAAPSGQ

Download         Length: 420 bp

>T200168 NZ_CP097719:2004814-2005068 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10101.47 Da        Isoelectric Point: 4.8839

>AT200168 WP_219320464.1 NZ_CP073764:3113151-3113426 [Methylovirgula sp. HY1]
MSDSGTAKIFMHGRSQAVRLPKEFRLPGQEVRVTRVGRGVLLEPIASDAKDIRAWFAELDRSGGADFLPEGRPEQPPMPP
EEVIFEDEPGK

Download         Length: 276 bp

>AT200168 NZ_CP097719:2004566-2004817 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References