Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2855030..2855817 Replicon chromosome
Accession NZ_CP073764
Organism Methylovirgula sp. HY1

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag MHY1_RS13380 Protein ID WP_219320252.1
Coordinates 2855314..2855817 (+) Length 168 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag MHY1_RS13375 Protein ID WP_219320251.1
Coordinates 2855030..2855317 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MHY1_RS13360 (MHY1_02736) 2851868..2853082 + 1215 WP_219320249.1 2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase -
MHY1_RS13365 (MHY1_02737) 2853172..2853561 + 390 WP_219320250.1 MAPEG family protein -
MHY1_RS13370 (MHY1_02738) 2853577..2854974 + 1398 WP_219323644.1 dihydrolipoyl dehydrogenase -
MHY1_RS13375 (MHY1_02739) 2855030..2855317 + 288 WP_219320251.1 DUF1778 domain-containing protein Antitoxin
MHY1_RS13380 (MHY1_02740) 2855314..2855817 + 504 WP_219320252.1 GNAT family N-acetyltransferase Toxin
MHY1_RS13385 (MHY1_02741) 2855875..2856708 - 834 WP_219320253.1 phage Gp37/Gp68 family protein -
MHY1_RS13390 (MHY1_02742) 2856860..2858491 + 1632 WP_255564919.1 GMC family oxidoreductase N-terminal domain-containing protein -
MHY1_RS13395 (MHY1_02743) 2858541..2859023 + 483 WP_219320254.1 MmcB family DNA repair protein -
MHY1_RS13400 (MHY1_02744) 2859107..2860276 + 1170 WP_219320255.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-147)

Antitoxin

Vibrio phage ICP1, Orf50

(11-87)


Sequences

Toxin        


Download         Length: 168 a.a.        Molecular weight: 18200.04 Da        Isoelectric Point: 10.3061

>T200167 WP_219320252.1 NZ_CP073764:2855314-2855817 [Methylovirgula sp. HY1]
VTRPLRIEKLQRTHVVDAFACGQADLDRFLIRHALQAQQANSSQTYVGLNGVKVVGYYTIVAGEVRHADAPARVTKGMPR
HPIPLLVLARLAVHREWQGRGLGAGLLLDALGRVLQAADIVGVRALAVHAKDDAAESFYKHFGFVPSPTDSRHLFILIKD
IRAAAGE

Download         Length: 504 bp

>T200167 NZ_CP097719:2004566-2004817 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11025.61 Da        Isoelectric Point: 8.8038

>AT200167 WP_219320251.1 NZ_CP073764:2855030-2855317 [Methylovirgula sp. HY1]
MPFEPTNRTEKLDLRLTKSAKRILQAAAMVARKSVSEFVLESALNEAEERLADRRVFTLDAERWEAFVAALDAPPRRHPR
LERLFREKSVFDPES

Download         Length: 288 bp

>AT200167 NZ_CP097719:2004814-2005068 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References