Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1-Phd |
| Location | 2324463..2325124 | Replicon | chromosome |
| Accession | NZ_CP073754 | ||
| Organism | Methylomonas paludis strain S2AM | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | KEF85_RS10475 | Protein ID | WP_215580268.1 |
| Coordinates | 2324705..2325124 (+) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | KEF85_RS10470 | Protein ID | WP_215580266.1 |
| Coordinates | 2324463..2324708 (+) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KEF85_RS10445 (KEF85_10450) | 2320650..2321405 | + | 756 | WP_246534864.1 | substrate-binding domain-containing protein | - |
| KEF85_RS10450 (KEF85_10455) | 2321485..2322060 | + | 576 | WP_215580260.1 | c-type cytochrome | - |
| KEF85_RS10455 (KEF85_10460) | 2322130..2322204 | + | 75 | WP_215585123.1 | pyrroloquinoline quinone precursor peptide PqqA | - |
| KEF85_RS10460 (KEF85_10465) | 2322608..2323375 | - | 768 | WP_215580262.1 | SDR family NAD(P)-dependent oxidoreductase | - |
| KEF85_RS10465 (KEF85_10470) | 2323912..2324061 | + | 150 | WP_215580264.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| KEF85_RS10470 (KEF85_10475) | 2324463..2324708 | + | 246 | WP_215580266.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KEF85_RS10475 (KEF85_10480) | 2324705..2325124 | + | 420 | WP_215580268.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| KEF85_RS16945 | 2325169..2325297 | - | 129 | WP_281413632.1 | hypothetical protein | - |
| KEF85_RS10480 (KEF85_10485) | 2325781..2326101 | + | 321 | WP_215580271.1 | type II toxin-antitoxin system PrlF family antitoxin | - |
| KEF85_RS10485 (KEF85_10490) | 2326101..2326553 | + | 453 | WP_215580273.1 | type II toxin-antitoxin system YhaV family toxin | - |
| KEF85_RS10490 (KEF85_10495) | 2326744..2327346 | - | 603 | WP_215580275.1 | group II intron maturase-specific domain-containing protein | - |
| KEF85_RS10495 (KEF85_10500) | 2327527..2327706 | - | 180 | WP_215580277.1 | hypothetical protein | - |
| KEF85_RS10500 (KEF85_10505) | 2327733..2327909 | - | 177 | WP_215580279.1 | hypothetical protein | - |
| KEF85_RS10505 (KEF85_10510) | 2327909..2329078 | - | 1170 | WP_215580281.1 | putative DNA binding domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15690.13 Da Isoelectric Point: 6.4525
>T200160 WP_215580268.1 NZ_CP073754:2324705-2325124 [Methylomonas paludis]
MNYLLDTCVLSELIKPQPNQNVATWIEKIQECHLYISALTMGEIQKGISRLENSKKKQSLQIWLEQDLAARFSGRILSVD
AEISLEWGNMQGQAIRSGTTLPVIDSLIAATAKCHNLTLVTRNLEDFKNLPINLNNPWL
MNYLLDTCVLSELIKPQPNQNVATWIEKIQECHLYISALTMGEIQKGISRLENSKKKQSLQIWLEQDLAARFSGRILSVD
AEISLEWGNMQGQAIRSGTTLPVIDSLIAATAKCHNLTLVTRNLEDFKNLPINLNNPWL
Download Length: 420 bp
>T200160 NZ_CP097719:c44937-44560 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9185.37 Da Isoelectric Point: 5.6864
>AT200160 WP_215580266.1 NZ_CP073754:2324463-2324708 [Methylomonas paludis]
MHWQLQEAKNKLSQVIHEAQTTGPQTITVRGKETAVVISAADYQKLTDKKDSLLKFFQESPLTDVELDLTRSKESGRDIE
L
MHWQLQEAKNKLSQVIHEAQTTGPQTITVRGKETAVVISAADYQKLTDKKDSLLKFFQESPLTDVELDLTRSKESGRDIE
L
Download Length: 246 bp
>AT200160 NZ_CP097719:c45395-45027 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCATGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCATGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|