Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1554263..1554915 Replicon chromosome
Accession NZ_CP073754
Organism Methylomonas paludis strain S2AM

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KEF85_RS07145 Protein ID WP_246535067.1
Coordinates 1554263..1554664 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KEF85_RS07150 Protein ID WP_215584498.1
Coordinates 1554673..1554915 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEF85_RS07115 (KEF85_07120) 1549383..1549610 + 228 WP_215584486.1 HypC/HybG/HupF family hydrogenase formation chaperone -
KEF85_RS07120 (KEF85_07125) 1549607..1550713 + 1107 WP_215584488.1 hydrogenase formation protein HypD -
KEF85_RS07125 (KEF85_07130) 1550757..1551791 + 1035 WP_281413692.1 hydrogenase expression/formation protein HypE -
KEF85_RS16900 1551943..1552071 - 129 WP_281413693.1 hypothetical protein -
KEF85_RS16905 1552188..1552322 - 135 WP_281413694.1 hypothetical protein -
KEF85_RS07130 (KEF85_07135) 1552396..1552569 - 174 WP_215584490.1 hypothetical protein -
KEF85_RS07135 (KEF85_07140) 1552646..1552822 - 177 WP_215584492.1 hypothetical protein -
KEF85_RS16910 1552939..1553070 - 132 WP_281413695.1 hypothetical protein -
KEF85_RS07140 (KEF85_07145) 1553740..1554135 + 396 WP_215584494.1 hypothetical protein -
KEF85_RS07145 (KEF85_07150) 1554263..1554664 - 402 WP_246535067.1 type II toxin-antitoxin system VapC family toxin Toxin
KEF85_RS07150 (KEF85_07155) 1554673..1554915 - 243 WP_215584498.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KEF85_RS07155 (KEF85_07160) 1555705..1556283 - 579 WP_215584500.1 hypothetical protein -
KEF85_RS07160 (KEF85_07165) 1556484..1556855 - 372 WP_215584502.1 hypothetical protein -
KEF85_RS07165 (KEF85_07170) 1556932..1557189 - 258 WP_215584504.1 hypothetical protein -
KEF85_RS07170 (KEF85_07175) 1557682..1558239 - 558 WP_215584506.1 recombinase family protein -
KEF85_RS07175 (KEF85_07180) 1558244..1558621 - 378 WP_215584508.1 DUF5615 family PIN-like protein -
KEF85_RS07180 (KEF85_07185) 1558618..1558848 - 231 WP_215584510.1 DUF433 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1557682..1558239 557


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-119)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14589.99 Da        Isoelectric Point: 6.0686

>T200157 WP_246535067.1 NZ_CP073754:c1554664-1554263 [Methylomonas paludis]
MLDTNTVSYIIKNHPPEIRKRLASLPMDSITISAVTQGELLYGLARKGYPATLAKLIREFLFRVETLPWDEQAASVYGDL
RASCMTVGISLGALDMMIAAHAIAANTILVSHDKAFSLVPDGVLTIEDWMHGF

Download         Length: 402 bp

>T200157 NZ_CP097717:c162274-161876 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9324.62 Da        Isoelectric Point: 6.2206

>AT200157 WP_215584498.1 NZ_CP073754:c1554915-1554673 [Methylomonas paludis]
MHTTAKLFVTGRSQALRLPKEFRFHGTEVYIRRDPMTGEVILSPKPASWAEFFELADHTKIPADFMTDREDLPSQERDLF

Download         Length: 243 bp

>AT200157 NZ_CP097717:c162501-162274 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References