Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 835734..837490 | Replicon | chromosome |
| Accession | NZ_CP073741 | ||
| Organism | Burkholderia pseudomallei strain AW9 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | B1H5R2 |
| Locus tag | KEX42_RS21075 | Protein ID | WP_004524002.1 |
| Coordinates | 835734..836639 (+) | Length | 302 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | B1H5R3 |
| Locus tag | KEX42_RS21080 | Protein ID | WP_004532863.1 |
| Coordinates | 836636..837490 (+) | Length | 285 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KEX42_RS21045 (KEX42_21045) | 831129..832217 | - | 1089 | WP_004184835.1 | porin | - |
| KEX42_RS21050 (KEX42_21050) | 832652..832969 | + | 318 | WP_004184916.1 | non-heme iron oxygenase ferredoxin subunit | - |
| KEX42_RS21055 (KEX42_21055) | 832971..833282 | + | 312 | WP_004532856.1 | hypothetical protein | - |
| KEX42_RS21060 (KEX42_21060) | 833317..834384 | + | 1068 | WP_004195457.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| KEX42_RS21065 (KEX42_21065) | 834381..835151 | + | 771 | WP_004184755.1 | SDR family oxidoreductase | - |
| KEX42_RS21070 (KEX42_21070) | 835190..835717 | + | 528 | WP_004524001.1 | cupin domain-containing protein | - |
| KEX42_RS21075 (KEX42_21075) | 835734..836639 | + | 906 | WP_004524002.1 | alpha/beta fold hydrolase | Toxin |
| KEX42_RS21080 (KEX42_21080) | 836636..837490 | + | 855 | WP_004532863.1 | IclR family transcriptional regulator | Antitoxin |
| KEX42_RS21085 (KEX42_21085) | 837487..838284 | + | 798 | WP_004195447.1 | SDR family oxidoreductase | - |
| KEX42_RS21090 (KEX42_21090) | 838277..839950 | + | 1674 | WP_004532795.1 | thiamine pyrophosphate-binding protein | - |
| KEX42_RS21095 (KEX42_21095) | 839943..840758 | + | 816 | WP_004195445.1 | aspartate dehydrogenase | - |
| KEX42_RS21100 (KEX42_21100) | 840784..842274 | + | 1491 | WP_004524006.1 | aldehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 302 a.a. Molecular weight: 30556.69 Da Isoelectric Point: 8.4944
>T200143 WP_004524002.1 NZ_CP073741:835734-836639 [Burkholderia pseudomallei]
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP
Download Length: 906 bp
>T200143 NZ_CP097716:c3691095-3690793 [Escherichia coli]
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTGTCTGGGAAATTACAGGAATATTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTGTCTGGGAAATTACAGGAATATTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
Antitoxin
Download Length: 285 a.a. Molecular weight: 31151.58 Da Isoelectric Point: 7.4022
>AT200143 WP_004532863.1 NZ_CP073741:836636-837490 [Burkholderia pseudomallei]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFNVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFNVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR
Download Length: 855 bp
>AT200143 NZ_CP097716:c3690757-3690416 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTACTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAATAATCGTAAACTCACCACTG
AAATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTACTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAATAATCGTAAACTCACCACTG
AAATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|