Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 267536..269295 Replicon chromosome
Accession NZ_CP073729
Organism Burkholderia pseudomallei strain BD5

Toxin (Protein)


Gene name hipA Uniprot ID Q63JY0
Locus tag KEX46_RS18935 Protein ID WP_004188815.1
Coordinates 267943..269295 (+) Length 451 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID C4I768
Locus tag KEX46_RS18930 Protein ID WP_004536731.1
Coordinates 267536..267946 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEX46_RS18920 (KEX46_18920) 264073..266469 - 2397 WP_045588572.1 cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB -
KEX46_RS18925 (KEX46_18925) 266935..267198 + 264 WP_004199789.1 hypothetical protein -
KEX46_RS18930 (KEX46_18930) 267536..267946 + 411 WP_004536731.1 helix-turn-helix domain-containing protein Antitoxin
KEX46_RS18935 (KEX46_18935) 267943..269295 + 1353 WP_004188815.1 type II toxin-antitoxin system HipA family toxin Toxin
KEX46_RS18940 (KEX46_18940) 269452..269904 - 453 WP_004198842.1 hypothetical protein -
KEX46_RS18945 (KEX46_18945) 270005..270151 - 147 WP_004199790.1 hypothetical protein -
KEX46_RS18950 (KEX46_18950) 270321..271235 - 915 WP_004198844.1 LysR family transcriptional regulator -
KEX46_RS18955 (KEX46_18955) 271402..272355 + 954 WP_004187785.1 agmatinase -
KEX46_RS18960 (KEX46_18960) 272626..272967 + 342 WP_004539420.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-408)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-71)


Sequences

Toxin        


Download         Length: 451 a.a.        Molecular weight: 49848.83 Da        Isoelectric Point: 9.6807

>T200137 WP_004188815.1 NZ_CP073729:267943-269295 [Burkholderia pseudomallei]
VSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHALADADIARLLREVTSAPQAGRHAPLDDLRLSI
AGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVV
ERFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIVFWLLAATDGHAK
NFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKHIHYPLHQIRRRHWIAQGQRVGFAPADVDALI
DTLTARTADVVDAVSARLPRDFPRDVADAIFSGMLGLSARLAGDAAARAP

Download         Length: 1353 bp

>T200137 NZ_CP097716:2008435-2008689 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14508.87 Da        Isoelectric Point: 11.8540

>AT200137 WP_004536731.1 NZ_CP073729:267536-267946 [Burkholderia pseudomallei]
MAILIEHEIKTLGQLRPILRGFRKSAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRALDIELTLTLTQVYAA
PAGKDKGEVAKTAAGARARAGARRAVPPASAPAPSAAGRAPRPARKRAAPKKREDW

Download         Length: 411 bp

>AT200137 NZ_CP097716:2008187-2008438 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TGCTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N4FSX2

Antitoxin

Source ID Structure
AlphaFold DB A0A7V8KZI9

References