Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1919122..1919957 Replicon chromosome
Accession NZ_CP073719
Organism Escherichia coli strain CX12

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1X9TM58
Locus tag J6O05_RS09330 Protein ID WP_000854761.1
Coordinates 1919122..1919499 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag J6O05_RS09335 Protein ID WP_001295723.1
Coordinates 1919589..1919957 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O05_RS09295 (1914641) 1914641..1915114 + 474 WP_001105385.1 DNA gyrase inhibitor SbmC -
J6O05_RS09300 (1915313) 1915313..1916371 + 1059 WP_001200892.1 FUSC family protein -
J6O05_RS09305 (1916543) 1916543..1916872 + 330 WP_000450409.1 DUF496 family protein -
J6O05_RS09310 (1916973) 1916973..1917338 - 366 WP_001282181.1 EutP/PduV family microcompartment system protein -
J6O05_RS09315 (1917609) 1917609..1917956 - 348 WP_001333417.1 IS110 family transposase -
J6O05_RS09320 (1918796) 1918796..1918876 - 81 Protein_1821 hypothetical protein -
J6O05_RS09325 (1918976) 1918976..1919125 - 150 Protein_1822 DUF5983 family protein -
J6O05_RS09330 (1919122) 1919122..1919499 - 378 WP_000854761.1 TA system toxin CbtA family protein Toxin
J6O05_RS09335 (1919589) 1919589..1919957 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
J6O05_RS09340 (1920120) 1920120..1920341 - 222 WP_000692345.1 DUF987 domain-containing protein -
J6O05_RS09345 (1920404) 1920404..1920880 - 477 WP_001186711.1 RadC family protein -
J6O05_RS09350 (1920895) 1920895..1921368 - 474 WP_000855059.1 antirestriction protein -
J6O05_RS09355 (1921710) 1921710..1922528 - 819 WP_001234729.1 DUF932 domain-containing protein -
J6O05_RS09360 (1922646) 1922646..1922841 - 196 Protein_1829 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14205.25 Da        Isoelectric Point: 7.3249

>T200111 WP_000854761.1 NZ_CP073719:c1919499-1919122 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T200111 NZ_CP097711:2119603-2119705 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT200111 WP_001295723.1 NZ_CP073719:c1919957-1919589 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT200111 NZ_CP097711:c2119743-2119475 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X9TM58

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References